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Diss Factsheets
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EC number: 203-898-4 | CAS number: 111-71-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Inhalation: LC50 > 18.6 mg/l for female and male rats (similar to OECD Guideline 403).
Oral: LD50 > 5000 mg/kg bw (similar to OECD Guideline 401).
Dermal: no reliable study is available.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This acute oral study is classified as reliable with restriction considering that the report is very succinct.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: no data
- Fasting period before study: no data
- Housing:no data
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum):no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: no data - Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data
- Doses:
- 5 g/kg
- No. of animals per sex per dose:
- 10 (no information on sex)
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data
- Other examinations performed: no data - Statistics:
- No statistics were performed.
- Preliminary study:
- Not concerned.
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Sex:
- not specified
- Dose descriptor:
- LD0
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- No mortality was observed.
- Clinical signs:
- other: Lethargy and piloerection were reported.
- Gross pathology:
- no data
- Other findings:
- None
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EU and CLP classifications
- Conclusions:
- Under the conditions of this test, Heptanal did not induce any mortality among the animals at the tested dose level of 5000 mg/kg.
- Executive summary:
In an acute oral toxicity study, 10 rats were given a single oral dose of heptanal at a dose level of 5000 mg/kg bw and observed for 14 days. No death occurred during the course of the study. Lethargy and piloerection were the only clinical signs reported. LD0 = 5000 mg /kg bw in rats.
Under the conditions of this test, heptanal is therefore not classified according to EU and GHS classifications.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: 2d Test procedure in accordance with national standard methods with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Shell Toxicology Laboratory (Tunstall)
- Age at study initiation: 10 weeks
- Weight at study initiation: males 251-328 g; females 180 - 220 g
- Fasting period before study: no data
- Housing: individually
- Diet : ad libitum (PRD, Labsure Animal Foods Ltd.)
- Water : ad libitum (filtered but untreated water from the public supply)
- Acclimation period: Rats were bred in the Shell Toxicology Laboratory.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): approximately 20
- Humidity (%): 58-70
- Air changes (per hr): no data
- Photoperiod : 12 hrs dark / 12 hrs light
IN-LIFE DATES: no data - Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: two tubular glass chambers
- Exposure chamber volume: 7 l
- Method of holding animals in test chamber: no data
- Source and rate of air: The test atmosphere was supplied at a minimal flow rate of 10 litres per minute
- Method of conditioning air: no data
- System of generating particulates/aerosols: the test atmosphere was generated by passing 3 to 4 l min -1 of nitrogen through a wick type saturator maintained at 78°C in a thermostated water bath. The vapou/air mixture was diluted with air at a flow rate of approximately 16 l min -1 before delivery to two identical, glass inhalation chambers each of volume 7 litres.
- Treatment of exhaust air: no data
- Temperature, humidity, pressure in air chamber: no data
TEST ATMOSPHERE
- Brief description of analytical method used: The concentration of the heptanal in the test atmosphere was measured continuously throughout the exposure by means of a Miran infra-red gas analyser. The latter was calibrated by injecting known volumes of heptanal into a closed loop circulating system also of known volume including the analyser gas cell.
- Samples taken from breathing zone: no - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 18.4 mg/l
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The animals were observed for toxic signs at frequent intervals throughout the exposure. Afterwards animals were observed daily for toxic signs over the following 14 days. Body weights were recorded initially and after 7 and 14 days.
- Necropsy of survivors performed: no
- Other examinations performed: no data - Statistics:
- Studen's t test was used to compare body weight between treated and control animals.
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- > 18.4 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: Exposure concentration was near saturated
- Mortality:
- The one male rat that died within 5 minutes of the cessation of exposure was examined histopathologically. Since no other rats died or showed any macroscopic abnormalities at necropsy, it was concluded that the single death was not directly related to exposure.
- Clinical signs:
- other: Signs of intoxication that persited throughout the exposure period included rapid respiration, eye and nasal irritation, salivation and a general state of agitation. The female rats recovered within 48 hours, however some of the signs persisted in the mal
- Body weight:
- Body weights of the exposed group of animals increased normally during the observation period and mean body weights of the test and control groups were not significantly different (Studen's t test)
- Gross pathology:
- No data
- Other findings:
- No data
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EU and CLP classification
- Conclusions:
- Under the conditions of this test, no mortality was directly related to the exposure.
- Executive summary:
In an acute inhalation toxicity study (Shell, 1982), a group of 5 male and 5 female rats was exposed for 4 hours to a mean concentration of 18.4 mg/l of heptanal a near saturated atmosphere. Signs of intoxication that persited throughout the exposure period included rapid respiration, eye and nasal irritation, salivation and a general state of agitation. The female rats recovered within 48 hours, however some of the signs persisted in the male rats for the whole of the 14 day post exposure period. Body weights of the exposed group of animals increased normally during the observation period and mean body weights of the test and control groups were not significantly different (Studen's t test). The one male rat that died within 5 minutes of the cessation of exposure was examined histopathologically. Since no other rats died or showed any macroscopic abnormalities at necropsy, it was concluded that the single death was not directly related to exposure. Then, the acute 4 h inhalation LC50 (and LC0) of heptanal in Wistar rats is greater than 18.4 mg/l a concentration which is near saturated.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating conc.
- Value:
- 18.6 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute oral toxicity:
In an acute toxicity study (Moreno, 1974), rats were administered a single oral dose of heptanal at 5000 mg/kg bw and observed for 14 days. No deaths were reported. Lethargy and piloerection were the only signs reported. The oral LD50 value was greater than 5000 mg/kg bw.
Acute inhalation toxicity:
Several data are available for this endpoint.
In the key study (Blair, 1982), a group of 5 male and 5 female rats were exposed for 4h to near saturated atmosphere of heptanal. Since no deaths occurred, the acute 4 h inhalation LC50 of heptanal in Wistar rats is greater than 18.4 mg/l, a concentration which is near saturated.
In the Hoffman supporting study (1989), 3 male and 3 female rats were exposed to heptanal vapor for a single four hour inhalation exposure at a measured concentration of 4.7 mg/l. Signs indicating irritation of the respiratory tract were observed during the exposure, but reversed quickly after the exposure ended. No mortality, signs of toxicity, or body weight changes were observed during a one week observation period. In another supporting study (Eschbach, 1981), four hour inhalation exposures of rats to measured aerosol concentrations of 0.23 and 0.52 mg/l did not produce mortality. Both concentrations caused body weight losses in all animals which did not recover until the second week post-exposure. Signs of respiratory and eye irritation of approximately equal incidence were observed in both groups. Eye effects included corneal opacities which increased or persisted during the 14 day post-exposure period.
In conclusion, heptanal has a low acute systemic toxicity following single exposure by inhalation.
Acute dermal toxicity:
No reliable data.
Justification for classification or non-classification
Based on these data, Heptanal is not classified for acute toxicity according to EU regulation (EC) No 1272/2008 (CLP), respectively.
Acute oral: not classified (LD50 > 5000 mg/kg; no mortality was observed)
Acute inhalation: not classified but data are inconclusive (LC50 > 18.4 mg/l; no death due to test material administration was observed; 18.4 mg/l is the satured concentration therefore no other study with higher concentration is possible).
Acute dermal: not classified because data lacking.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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