Registration Dossier
Registration Dossier
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EC number: 268-387-0 | CAS number: 68083-38-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from authoritative database
Data source
Reference
- Reference Type:
- other: Authoritive data base
- Title:
- Skin irritation CAS No: 121573 (Sulfanilic acid)
- Author:
- IFA (GESTIS)
- Year:
- 2 016
- Bibliographic source:
- GESTIS Substance Database (Information System in Hazardous Substance of the Berufsgenossenscheftn), 2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Skin irritation study was conducted in rabbits for test chemical 4-Aminobenzenesulfonic acid (CAS no: 121573) to determine its skin effects.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sulphanilic acid
- EC Number:
- 204-482-5
- EC Name:
- Sulphanilic acid
- Cas Number:
- 121-57-3
- Molecular formula:
- C6H7NO3S
- IUPAC Name:
- 4-aminobenzenesulfonic acid
- Test material form:
- solid
- Details on test material:
- - Name of test material (as cited in study report): 4Aminobenzenesulfonic acid
- Molecular formula: C6H7NO3S
- Molecular weight: 173.19 g/mol
- Substance type: organic
- Physical state: solid
- Smiles notation: S(c1ccc(N)cc1)(O)(=O)=O
- InChl: 1S/C6H7NO3S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H,8,9,10)
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 4Aminobenzenesulfonic acid
- Molecular formula: C6H7NO3S
- Molecular weight: 173.19 g/mol
- Substance type: organic
- Physical state: solid
- Smiles notation: S(c1ccc(N)cc1)(O)(=O)=O
- InChl: 1S/C6H7NO3S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H,8,9,10)
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 500mg
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24 hours
- Number of animals:
- No data
- Details on study design:
- No data
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- slight irritating effcts were observed.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- 4-Aminobenzenesulfonic acid (CAS No: 121573) was observed to be slightly irritating on rabbits skin.
- Executive summary:
A skin irritation test was carried out in rabbits to determine the skin irritation potency of test chemical 4-Aminobenzenesulfonic acid (CAS No: 121573)
500mg of test sample was applied on rabbits skin and the rabbits were observed for signs of irritation till 24 hours.
Since the rabbits produced slight irritation reactions within 24 hours, 4-Aminobenzenesulfonic acid (CAS No: 121573) was considered as irritating on rabbit skin.
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