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reaction mass of: pentasodium bis[6-anilino-3,5'-disulfonatonaphthalene-2-azobenzene-1,2'-diolato]cobaltate(III);tetrasodium [6-anilino-3,5'-disulfonatonaphthalene-2-azobenzene-1,2'-diolato][6-anilino-5'-sulfamoyl-3-sulfonatonaphthalene-2-azobenzene-1,2'-diolato]cobaltate(III);trisodium bis[6-anilino-5'-sulfamoyl-3-sulfonatonaphthalene-2-azobenzene-1,2'-diolato]cobaltate(III)
EC number: 444-290-0 | CAS number: 508202-43-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Not skin irritant
Category 1 (irreversible effects on the eye)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
SKIN IRRITATION
The skin irritation test was performed to rabbit skin according to the OECD Guidelines 404 (1992) and the method B.4 of EEC-Directive 92/69 EEC. 0.5 g of test item were applied (semi-occlusive system) to the intact left flank of 3 young adult New Zealand White rabbits. The duration of treatment was 4 hours.
The test substance was found to be not irritant when applied to intact rabbit skin: local signs (mean values 24/48/72 hours) consisted of grade 0 erythema and grade 0 oedema in all animals. The test item caused a marked violet coloured staining at the test site of all animals 1 hour after removal of the dressing. A light violet staining continued to be observed in one animal up to the 72-hour examination and in the remaining two animals up to the 7-day examination. Thus this effect was reversable within the study period (10 days).
No corrosive effects were noted on the treated skin of any animal at any of the measuring intervals.
EYE IRRITATION/CORROSION
The eye irritation test was performed to the rabbit eye according to OECD Guidelines 405 (2002) and the method B.5 of EEC-Directive 92/69 EEC. 0.1 g of test item were installed into the left eye of 3 young adult New Zealand White rabbits. Scoring of irritation effects was performed after test item application at 1, 24, 48 and 72 hour, as well as 7, 10, 14, 17 and 21 day.
Mean values at 24, 48 and 72 hours for iris were 0.00 in all animals. The other mean values for corneal opacity were 0.00, 0.00 and 1.00; for the conjunctivae were 1.33, 1.00 and 1.33 (redness) and 0.00, 0.00 and 0.33 (chemosis), respectively in animals #1, #2 and #3. These effects were reversible and were no longer evident 21 days after treatment, the end of the observation period for all animals.
No corrosion was observed at any of the measuring intervals.
A slight opacity of the cornea was noted in one animal due to the staining produced by the test item. Marked violet staining caused by the test item was evident in all animals at the 1-hour reading. Light to marked violet staining was then observed in all animals up to 7 days. Light violet staining persisted in one animal up to termination.
Thus, the test item induced irreversible damage to the rabbit eye: the violet coloured staining which persisted in one animal throughout the observation period.
Justification for classification or non-classification
SKIN IRRITATION
In the CLP Regulation (EC 1272/2008), skin irritation is defined as "the production of reversible damage to the skin following the application of a test substance for up to 4 hours." A single irritant category (Category 2) is defined and, using the results of animal testing, the classification criteria are presented in Annex I, Part 3, Table 3.2.2.
Based on the results of Acute Dermal Irritation/Corrosion study conducted on the test substance, the mean score (24/48/72h) of erythema and edema was not in the range of ≥ 2.3 - ≤ 4.0 therefore the substance is not classified for skin irritation according to the CLP Regulation (EC 1272/2008).
EYE IRRITATION/CORROSION
The CLP Regulation (EC 1272/2008) defines Serious eye damage as “the production of tissue damage in the eye, or serious physical decay of vision, following application of a test substance to the anterior surface of the eye, which is not fully reversible within 21 days of application”. A substance that has the potential to seriously damage the eyes is classified in Category 1 (irreversible effects on the eye).
On the basis of the results of animal testing, the classification criteria are presented in Annex I, Part 3, Table 3.3.1.
Based on the results of Acute Eye Irritation/Corrosion study conducted, the substance was found to cause light violet staining persisted in one animal up to study period termination (21 days). Therefore, the test substance should be classified according to the CLP Regulation (EC n. 1272/2008) Eye Dam. 1.
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