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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 204-371-1 | CAS number: 120-12-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study based on scientific principles, reproducible test method
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 963
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Delayed hypersensitivity/contact sensitisation: Intradermal injection of the agents into the foot pad for induction in the presence of Freund´s adjuvant, followed by topical/epidermal challenge
(method according to: Gell PG and Benacerraf B J. Exp. Med. 113, 571 (1961) - GLP compliance:
- no
- Type of study:
- intracutaneous test
Test material
- Reference substance name:
- Anthracene
- EC Number:
- 204-371-1
- EC Name:
- Anthracene
- Cas Number:
- 120-12-7
- Molecular formula:
- C14H10
- IUPAC Name:
- anthracene
- Details on test material:
- commercial (Eastman Kodak), no further data
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- female
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: intradermal into each front food pad
- Vehicle:
- other: acetone-olive oil mixture (no further data)
- Concentration / amount:
- 0.001, 0.01, 0.1, and 1 %
Challengeopen allclose all
- Route:
- epicutaneous, open
- Vehicle:
- other: acetone-olive oil mixture (no further data)
- Concentration / amount:
- 0.001, 0.01, 0.1, and 1 %
- No. of animals per dose:
- no data [note: 6, 16, and 10 were used for 3-methylcholanthrene (MC), BaP and 9,10-dimethyl-1,2-benzanthracene (DMBA), respectively]
- Details on study design:
- RANGE FINDING TESTS: no data
MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 1
- Exposure period: 2 - 3 weeks
- Test groups: 4
- Control group: 1
- Site: each foot pad
- Frequency of applications: 1x
- Concentrations: 250 µg (125 µg/0.1 mL)
- Auxiliary agent: emulsion in complete Freund´s adjuvant with saline
B. CHALLENGE EXPOSURE
- No. of exposures: 1
- Day(s) of challenge: 2 - 3 weeks after induction
- Exposure period: 24 h
- Test groups: 4
- Control group: 1
- Site: ventral or dorsal shaved skin
- Concentrations: 0.001, 0.01, 0.1,and 1 % (one drop each applied)
- Evaluation (hr after challenge): 24
OTHER:
- Scoring system
according to Gell PG and Benacerraf B J. Exp. Med. 113, 571 (1961): from +++ - 0 - Challenge controls:
- PAH known to be contact sensitisers in this test system: BaP, MC, and DMBA.
- Positive control substance(s):
- yes
- Remarks:
- BaP, MC, and DMBA
Results and discussion
- Positive control results:
- MC +++ (>= 0.1 %); BaP +++ (>= 0.1 %); DMBA +++ (1 %).
Dose-related intensity of the responses
Cross-reactivity primarily seen at the higher challenge doses.
In vivo (non-LLNA)
Resultsopen allclose all
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 0.001 - 1 %
- Clinical observations:
- reponse - to +- (slight erythema)
- Remarks on result:
- other: . Hours after challenge: 24.0. Group: negative control. Dose level: 0.001 - 1 %. Clinical observations: reponse - to +- (slight erythema).
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 0.001 - 1 %
- Clinical observations:
- no difference from control
- Remarks on result:
- other: . Hours after challenge: 24.0. Group: test group. Dose level: 0.001 - 1 %. Clinical observations: no difference from control .
Any other information on results incl. tables
Note: Phenanthrene concomitantly examined also failed to show a sensitising potential.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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