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Diss Factsheets
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EC number: 907-132-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, Non-Guideline
- Justification for type of information:
- Read across is based on the category approach. Please refer to attached category document.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
- Principles of method if other than guideline:
- Daphnia reproduction and survival over 21 days
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,2'-(ethylenedioxy)diethanol
- EC Number:
- 203-953-2
- EC Name:
- 2,2'-(ethylenedioxy)diethanol
- Cas Number:
- 112-27-6
- Molecular formula:
- C6H14O4
- IUPAC Name:
- 2,2'-[ethane-1,2-diylbis(oxy)]diethanol
- Test material form:
- not specified
- Details on test material:
- No additional information.
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Not applicable.
Sampling and analysis
- Analytical monitoring:
- no
- Details on sampling:
- No additional information.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Kanawha River water obtained from the South Side boat ramp is used in feed to holding vessels and for diluting test solution.
Fresh stock solution of test chemicals was prepared on Monday, Wednesday, and Friday.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Daphnia used in these chronic toxicity tests were obtained from a laboratory culture which was stocked from the EPA laboratory at Duluth, MN. Cultures are maintained at 21 - 23 degrees Celsius in series of 600 ml beakers filled with Kanawha River water. These cultures are transferred 3 times a week, new born are saved (20 per beaker) and fed with a laboratory prepared food consisting of trout food, yeast, and alfalfa powder.
Daphnia 1st instar were collected when they were about 24 hours old. The procedure for obtaining first instar is by isolating an adult culture that have gravid females who have produced young in the last 24 hours.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
- Post exposure observation period:
- No additional information.
Test conditions
- Hardness:
- Hardness: 55 mg/l as CaCO3
- Test temperature:
- Temperature was held at room temperature, 21-23 degrees Celsius, and no special control was used.
- pH:
- 6.7
- Dissolved oxygen:
- Dissolved oxygen concentration in each test chamber was measured and fell in the 60-100% of saturation. No aeration was used so there was no stripping from aeration.
- Salinity:
- Total alkalinity: 36 mg/l as CaCO3
- Nominal and measured concentrations:
- 0, 50, 250, 500, 1000, 2500 mg/l (nominal)
- Details on test conditions:
- All dilutions, stock solutions and standards were prepared in Kanawha River water. Food was prepared in dechlorinated tap water.
Set up 9-250 mL beakers for each test concentration and for control. The 1st 7 beakers of each concentration have only 1 daphnid in 200 mls. Two beakers of each concentration contain 5 daphnids in 200 mls and the reproduction of these are not counted, but are carried on for the 21 days to collect survival data. The adults are transferred on Monday, Wednesday, and Friday and the young are counted for each Daphnia and discarded. There usually is little or no reproduction until after 10 days.
Fresh stock solution of test chemicals was prepared on Monday, Wednesday, and Friday and 2 drops of food were added to each beaker and 10 drops for beakers with 5 daphnids.
Light cycle was maintinaed with 16 hours on and 8 hours off. - Reference substance (positive control):
- yes
- Remarks:
- sodium lauryl sulfate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 21 d
- Dose descriptor:
- other: NOAEC
- Effect conc.:
- 2 500 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 2 500 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- The reproduction levels for Daphnia exposed to selected concentrations of TEG are presented in the attached Tables (II and III). The data indicate no adverse effect on reproduction at test concentrations through 2500 mg/l. No significant difference in growth of the Daphnia was measured at the various TEG concentrations. The reproduction data in Tables II and III indicate a significant statistical increase in reproduction levels as the TEG concentration increased. This probably reflects the increased organic chemical food supply and a corresponding increase in bacterial populations.
- Results with reference substance (positive control):
- Sodium lauryl sulfate was selected as a QA standard chemical. The Daphnia reproduction data showed an statistical effect between 2.5 and 5 mg/l, which was in the expected range since acute toxicity was measured at 5 mg/l in a 48 hour test and 6.7-7.1 mg/l in the survival portion of this 21 day test. Growth measurements on exposed daphnids indicated approximately a 30 to 40 percent reduction in growth in going from the 2.5 mg/l and 5 mg/l dosage.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The reproduction levels for Daphnia exposed to selected concentrations of TEG are presented in the attached Tables (II and III). The data indicate no adverse effect on reproduction at test concentrations through 2500 mg/l. No significant difference in growth of the Daphnia was measured at the various TEG concentrations. The reproduction data in Tables II and III indicate a significant statistical increase in reproduction levels as the TEG concentration increased. This probably reflects the increased organic chemical food supply and a corresponding increase in bacterial populations.
- Executive summary:
TEG produced no adverse effect on Daphnia survival or reproduction at test concentrations through 2500 mg/l. The significant statistical increase in reproduction levels as the TEG concentration increased likely reflect the increased organic chemical food supply and a corresponding increase in bacterial populations.
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