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EC number: 218-880-1 | CAS number: 2273-43-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not specified
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Young adult albino rabbits of the New Zealand strain were used as test animals. Twenty-four hours prior to the dermal applications, the backs of the rabbits were shaved free of hair with electric clippers. A range of several dose levels was studied using 1 rabbit per level. The test site of each animal was covered by wrapping the trunk with impervious plastic sheeting which was securely taped in place. The test material remained in contact with the skin for 24 hours. At the end of this period, the plastic sheeting and all residual test material were removed. The test sites were examined for local skin reactions and the animals were returned to their cages. Observations for mortality, local skin reactions and behavioural abnormalities were continued for a total of 14 days following the skin applications. Initial, 7- and 14-day body weights were recorded. A necropsy examination was conducted on all animals.
- GLP compliance:
- no
- Remarks:
- study pre-dates GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Butylhydroxyoxostannane
- EC Number:
- 218-880-1
- EC Name:
- Butylhydroxyoxostannane
- Cas Number:
- 2273-43-0
- Molecular formula:
- C4H10O2Sn
- IUPAC Name:
- butyl(oxo)stannanol
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Appearance: white powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: young
- Weight at study initiation: 2.86 - 2.98 g
- Housing: The rabbits were housed individually in suspended, wire-bottomed cages
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: at least 7 days
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- the test material was applied as an aqueous slurry
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Back
- % coverage: 30%
- Twenty-four hours prior to the dermal applications, the backs of the rabbits were shaved free of hair with electric clippers. The shaved area on each animal constituted about 30 percent of the total body surface area. The animals were then returned to their cages to await testing on the following day. The 24-hour waiting period allowed recovery of the stratum corneum from the disturbance which accompanied the close-clipping procedure and permitted healing of any microscopic abrasions possibly produced during the process.
- Type of wrap if used: The test site of each animal was covered by wrapping the trunk with impervious plastic sheeting which was securely taped in place. This plastic wrap insured close contact of the epidermis and test material. To prevent oral ingestion of the test material, each animal was fitted with a lightweight, flexible plastic collar which was worn throughout the observation period.
REMOVAL OF TEST SUBSTANCE
- The test material remained in contact with the skin for 24 hours. At the end of this period, the plastic sheeting and all residual test material were removed.
TEST MATERIAL
- Applied as an aqueous slurry to abraded skin sites - Duration of exposure:
- 24 hours
- Doses:
- 200, 500 2000 mg/kg
- No. of animals per sex per dose:
- 1 animal per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Observations for mortality, local skin reactions and behavioural abnormalities were continued for a total of 14 days following the skin applications.
- Initial, 7- and 14-day body weights were recorded.
- A necropsy examination was conducted on all animals.
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred during the observation period.
- Clinical signs:
- other: No pharmacotoxic symptoms were observed in the rabbits following dermal exposure to the test material. The test material was non-irritating to the skin of the albino rabbit.
- Gross pathology:
- Necropsy examination revealed a cyst on the liver and a haemorrhage in the lung in rabbit 2-M. These lesions appeared to be associated with naturally occurring disease. No other gross pathologic alterations were found.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified in accordance with EU Criteria.
- Conclusions:
- Under the conditions of this study the acute dermal LD50 was greater than 2000 mg/kg.
- Executive summary:
The acute dermal toxicity of the test material was investigated using young adult male New Zealand White rabbits.
Twenty-four hours prior to the dermal applications, the backs of the rabbits were shaved free of hair with electric clippers. A range of several dose levels was studied using 1 rabbit per level. The test site of each animal was covered by wrapping the trunk with impervious plastic sheeting which was securely taped in place. The test material remained in contact with the skin for 24 hours. At the end of this period, the plastic sheeting and all residual test material were removed. The test sites were examined for local skin reactions and the animals were returned to their cages. Observations for mortality, local skin reactions and behavioural abnormalities were continued for a total of 14 days following the skin applications. Initial, 7- and 14-day body weights were recorded. A necropsy examination was conducted on all animals.
No mortality occurred during the observation period. No pharmacotoxic symptoms were observed in the rabbits following dermal exposure to the test material. The test material was non-irritating to the skin of the albino rabbit.
Necropsy examination revealed a cyst on the liver and a haemorrhage in the lung in rabbit 2-M. These lesions appeared to be associated with naturally occurring disease. No other gross pathologic alterations were found.
Under the conditions of this study the acute dermal LD50 was greater than 2000 mg/kg.
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