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Diss Factsheets
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EC number: 209-235-5 | CAS number: 562-74-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- 10 animals/group, no record of bodyweight/gain
- GLP compliance:
- no
- Remarks:
- pre-GLP study
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- p-menth-1-en-4-ol
- EC Number:
- 209-235-5
- EC Name:
- p-menth-1-en-4-ol
- Cas Number:
- 562-74-3
- Molecular formula:
- C10H18O
- IUPAC Name:
- 4-methyl-1-(propan-2-yl)cyclohex-3-en-1-ol
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Sample markings: 76-363, 4-TERPINENOL
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- oral: unspecified
- Doses:
- 0.6, 1.22, 2.47, and 5.0 g/kg
- No. of animals per sex per dose:
- 10 per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: at least once a day
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 300 mg/kg bw
- Based on:
- test mat.
- Mortality:
- In the 0.6 g/kg dose group one animal died. In the 1.22 g/kg dose group, 4 animals died. In the 2.47 g/kg dose group, 9 animals died and in the 5.0 g/kg dose group, all animals died. In all dose groups, the animals died on day 1 after administration of the test substance.
- Clinical signs:
- other: Symptomatology Rats: 0.6 g/kg - ataxia, lethargy, tremors, chromorhinorrhea, chromodacryorrhea 1.22 g/kg - lethargy, ptosis, pile-erection chromorhinorrhea 2.47 g/kg - salivation, chromorhinorrhea, ataxia 5.0 g/kg - coma and death
Any other information on results incl. tables
Necroscopy Observations
Dose g/kg |
0.6 |
1.22 |
2.47 |
5.0 |
Lungs dark |
1 |
4 |
9 |
9 |
Liver dark |
1 |
4 |
8 |
7 |
Areas of redness in intestines |
1 |
4 |
6 |
6 |
Kidneys dark |
1 |
2 |
2 |
3 |
Dried blood around eyes |
|
|
3 |
|
Yellow exudate - nose and mouth |
|
|
3 |
|
Portions of intestines yellow |
|
|
3 |
|
Portions of stomach red |
|
|
3 |
|
Bloody urine in bladder |
|
|
2 |
|
Red exudate - mouth |
|
|
2 |
|
Kidneys mottled |
|
3 |
1 |
|
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Under the conditions chosen and the results obtained, the test substance is considered to be classified as acute toxic category 4 (H302: harmful if swallowed). The LD50 was reported to be 1.3 g/kg.
- Executive summary:
An acute toxicity test via the oral route was performed pre-GLP. The test was equivalent or similar to the OECD guideline 401. Ten rats per dose group were treated with 0.6, 1.22, 2.47, and 5.0 g/kg of the test substance of which died at the first observation day 1/10, 4/10, 9/10, and 10/10, respectively. The LD50 was reported to be 1.3 g/kg. Necropsy observations revealed dark lungs, dark liver, dark kidneys, and areas of redness in intestines, among others.
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