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EC number: 210-894-6 | CAS number: 625-45-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of Dimethoxyethyl phtalate, Monomethoxyethyl phtalate, 2-Methoxyethanol and Methoxyacetic acid on post implantation rat embryos in culture
- Author:
- Yonemoto J, Brown NA, Webb M
- Year:
- 1 984
- Bibliographic source:
- Toxicology Letters, 21: 97-102.
Materials and methods
- Principles of method if other than guideline:
- Embryo culture system based on New (1978, Biol. Rev., 53: 81-122).
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Methoxyacetic acid
- EC Number:
- 210-894-6
- EC Name:
- Methoxyacetic acid
- Cas Number:
- 625-45-6
- Molecular formula:
- C3H6O3
- IUPAC Name:
- 2-methoxyacetic acid
- Reference substance name:
- 2-methoxyacetic acid
- IUPAC Name:
- 2-methoxyacetic acid
- Details on test material:
- Methoxyacetic acid (MMA) obtained from Aldrich Chemical Co. Ltd. (Gillingham, Dorset). No purity is indicated. MAA-Na was prepared based on the parent substance and used for testing.
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
Administration / exposure
- Details on mating procedure:
- Nulliparous female rats of the Wistar-Porton strain were mated overnight with males of the same strain (Day 0 of gestation represented the morning following mating). On Day 9 of gestation (embryonic age 9.5 days) rat conceptuses were removed aseptically and collected. The intact visceral yolk sacs and ectoplacental cones were retained, but Reichert's membranes were removed.
- Frequency of treatment:
- Rat conceptuses were transferred in pairs into 40-ml bottles that contained male rat serum (3 ml) and either MEM (1 ml; controls) or soIutions in this medium (1 ml) of the test compound.
- Duration of test:
- The cultures were grown in the absence of antibiotics for 46 h in gas phases with 5% (v/v) carbon dioxide at 37.5 ± 0.5°C. At the end of the culture period, rat conceptuses were transferred to Ringer's Solution and examined.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1, 2, 3, 4 mM
Basis:
nominal conc.
Examinations
- Statistics:
- Growth of the embryos was estimated by crown-rump and head length measurements. The degree of differentiation and development was evaluated by a morphological scoring system. The significance of the results was assessed by Student's t test.
Results and discussion
Results (fetuses)
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Any other information on results incl. tables
Rat embryos aged 9.5 days were incubated in vitro (in culture medium) for 46 hours. Malformations of the yolk sac, auditory pits, somites and neural groove were evident at concentrations of 1 mM Methoxyacetic acid (=90 µg/ml) and above. From 2 mM Methoxyacetic acid (=180 µg/ml), there was a significant decrease in the yolk sac diameter, the length from head to rump and the length of the skull (n=12). A reduced number of somites was found, too. All of the embryos (n=10) showed developmental anomalie(s) at a concentration of 5 mM (=451 µg/ml).
Applicant's summary and conclusion
- Executive summary:
In post-implantation rat embryonic cultures Methoxyacetic acid (1 - 5 mmol/L; 90 - 450 mg/l) interfered with normal growth and development of the early neurula stage. The NOEC was 1 mmol/L (Yonemoto et al, 1984).
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