Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 200-752-1 | CAS number: 71-41-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- For justification of read across please refer to section 13.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Smyth Jr. HF et al.
- Year:
- 1 962
- Bibliographic source:
- Am. Ind. Hyg. Ass. J., 23, 95-107
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- RIFM
- Year:
- 2 008
- Bibliographic source:
- RIFM database
Materials and methods
- Principles of method if other than guideline:
- modified acc. to Draize, J.H. et al., J. Pharmacol. Exp. Therap. 82, 377 (1944)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-methylbutan-1-ol
- EC Number:
- 205-289-9
- EC Name:
- 2-methylbutan-1-ol
- Cas Number:
- 137-32-6
- Molecular formula:
- C5H12O
- IUPAC Name:
- 2-methylbutan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): 2-Methylbutanol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5 - 3.5 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: trunk
- Type of wrap if used: impervious plastic film
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data
- Time after start of exposure: 24 h - Duration of exposure:
- 24 h
- Doses:
- no data
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- LD50 value and its fiducial range are estimated by the method of Thompson (1947) using the Tables of Weil (1952)
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3.54 mL/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 860 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: density = 0.808 g/cm3
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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