Registration Dossier
Registration Dossier
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EC number: 201-719-4 | CAS number: 87-03-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed journal
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- ASSESSMENT OF THE ACUTE TOXICITY AND POTENTIAL IRRITANCY OF HAIR DYE CONSTITUENTS
- Author:
- G. K. LLOYO, M. P. LIGGETT, S. R. KYNOCH and R. E. DAVIES
- Year:
- 1 977
- Bibliographic source:
- Food and Cosmetics Toxicology Vol. 15, pp. 607-610. Pergamon Press 1977.
- Reference Type:
- review article or handbook
- Title:
- Resorcinol
- Author:
- World Health Organization (WHO).
- Year:
- 2 006
- Bibliographic source:
- The United Nations Environment Programme (UNEP); International Programme on Chemical Safety (IPCS); 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: According to the United States Code of Federal Regulations (Federal Hazardous Substances Act Regulations 16: Section 1500.42, Test for eye irritants)
- Principles of method if other than guideline:
- An eye irritation study of Resorcinol (CAS No: 108-46-3) was conducted on eye of three New Zealand White rabbits according to the United States Code of Federal Regulations (Federal Hazardous Substances Act Regulations 16: Section 1500.42, Test for eye irritants)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,3 benzenediol
- Cas Number:
- 108-46-3
- Molecular formula:
- C6H6O2
- IUPAC Name:
- 1,3 benzenediol
- Test material form:
- solid
- Details on test material:
- - Name of test material (as cited in study report): Resorcinol
- Molecular formula: C6H6O2
- Molecular weight: 110.1114 g/mol
- Substance type: organic
- Physical state: solid
-Smiles: c1c(cccc1O)O
-InChI: 1S/C6H6O2/c7-5-2-1-3-6(8)4-5/h1-4,7-8H
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Resorcinol
- Molecular formula: C6H6O2
- Molecular weight: 110.1114 g/mol
- Substance type: organic
- Physical state: solid
-Smiles: c1c(cccc1O)O
-InChI: 1S/C6H6O2/c7-5-2-1-3-6(8)4-5/h1-4,7-8H
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- No data available
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 2.5%
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 24 hours
- Number of animals or in vitro replicates:
- 3 rabbits
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): The eyes of all the rabbits were irrigated with 50 ml of lukewarm (37°C)
water, 10 sec after instillation of the test material
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- The chemical caused only mild conjunctival inflammation, disappearing within 24 h post-application.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not irritating
- Conclusions:
- The test material Resorcinol (CAS No: 108-46-3) was considered to be not irritating to eyes of three New Zealand White rabbits.
- Executive summary:
An eye irritation study of Resorcinol (CAS No: 108-46-3) was conducted on three New Zealand White rabbits according to the United States Code of Federal Regulations (Federal Hazardous Substances Act Regulations 16: Section 1500.42, Test for eye irritants)
The installation of 2.5% (w/v) solution of resorcinol into the eyes (rinsing 10 s after application) produced only mild conjunctival inflammation which was disappeared within 24 h post-application.
Since the ocular lesions were not persisted, the chemical Resorcinol (CAS No: 108-46-3) was considered to be not irritating to eyes of three New Zealand White rabbits.
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