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EC number: 294-705-2 | CAS number: 91745-35-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 days
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Modern GLP study conducted in accordance with modern guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Amines, bis(hydrogenated tallow alkyl), 2-[[bis(hydrogenated tallow alkyl)amino]carbonyl]benzoates
- EC Number:
- 294-705-2
- EC Name:
- Amines, bis(hydrogenated tallow alkyl), 2-[[bis(hydrogenated tallow alkyl)amino]carbonyl]benzoates
- Cas Number:
- 91745-35-6
- Molecular formula:
- C72H140N2O3-C80H156N2O3
- IUPAC Name:
- Amines, bis(hydrogenated tallow alkyl), 2-[[bis(hydrogenated tallow alkyl)amino]carbonyl]benzoates
- Details on test material:
- Batch number E0011-039E
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: albino
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Six female albino rats of approximately nine weeks of age were used in the study. They were individually housed during the study. The animal was maintained on a 12-hour light/dark cycle (06:00 to 18:00). Mean daily temperatures and humidities ranged from 20.8 to 21.4 deg C and 34 to 44% respectively.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 200 mg/ml
- Amount of vehicle (if gavage): 10 ml/kg bodyweight - Doses:
- 2,000 mg/kg bodyweight (limit test)
- No. of animals per sex per dose:
- 6 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days.
- Frequency of observations: 15 minutes, 1, 2 and 4 hours after dosing, and daily thereafter.
- Frequency of weighing: Day of dosing (Day 0), Day 7 and Day 14.
- Necropsy of survivors performed: yes/no Yes. - Statistics:
- Not performed. There were no deaths in the study.
Results and discussion
Effect levels
- Remarks on result:
- other: There were no deaths
- Mortality:
- There were no deaths
- Clinical signs:
- No clinical signs were observed, except for a transient decrease in size of faeces and/or decreased defecation in one animal during the first two days after dosing. This may have been due to the fasting period prior to dosing.
- Body weight:
- There were no remarkable bodyweight changes
- Gross pathology:
- There were no gross pathology findings.
Applicant's summary and conclusion
- Conclusions:
- The test material caused no mortality or signs of toxicity in this study. The acute oral LD50 of the test material in albino rats is greater than 2,000 mg/kg bodyweight.
- Executive summary:
An acute oral toxcity study (acute toxic class method - limit test) of was conducted in fasted female albino rats using a dose of 2,000 mg of test material per kg bodyweight. The test material was dissolved in corn oil and administered at a dosing volume of 10 ml/kg. Three animals were dosed and, when no deaths were observed after 48 hours, a confirmatory test using a further three females was conducted. In each case, animals were maintained for a 14 -day observation period.
This GLP study was conducted in accordance with OECD Test Guideline 423.
No animals died during the study and no signs of toxicity were observed in-life or at necropsy. The acute oral LD50 of the test material in albino rats is concluded to be >2,000 mg/kg bodyweight.
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