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EC number: 250-078-7 | CAS number: 30168-23-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-(tricyclo[5.2.1.02,6]dec-8-ylidene)butyraldehyde
- EC Number:
- 250-078-7
- EC Name:
- 4-(tricyclo[5.2.1.02,6]dec-8-ylidene)butyraldehyde
- Cas Number:
- 30168-23-1
- Molecular formula:
- C14H20O
- IUPAC Name:
- 4-[(8Z)-tricyclo[5.2.1.0^{2,6}]decan-8-ylidene]butanal
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Dupical.
Stored in the dark at room temperature.
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Eight male and eight female rabbits into 4 groups.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: Abraded and intact skin
- Vehicle:
- other: Soya bean oil
- Amount / concentration applied:
- 9 mL/kg bodyweight by appropriate dilution in soya bean oil.
- Duration of treatment / exposure:
- 24 hour exposure.
- Observation period:
- Two weeks.
- Number of animals:
- 16 rabbits (8 males and 8 females)
- Details on study design:
- Rabbits were shaved (approx: 10% of the trunk).
The test substance was placed onto shaved skin at dose levels of 0.0, 1.4, 2.8 and 5.6 ml/kg bw.
Half the animals received dose on intact skin and half on abraided skin.
The treated area was covered with a thin layer of cellulose sheet and wrapped in polyethylene foil.
After 24 hours, the test substance was romoved by washing with water.
Rabbits were observed for up to 2 weeks.
After 2 weeks blood composition and macroscopic appearance of heart, liver, kidneys, spleen and stomach were examined histologically.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24hr and 72hr mean
- Score:
- 2.75
- Max. score:
- 4
- Reversibility:
- other: Not assessed
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24hr and 72hr mean
- Score:
- 1.6
- Max. score:
- 4
- Reversibility:
- other: Not assessed
- Remarks on result:
- probability of moderate irritation
- Irritation parameter:
- erythema score
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Remarks:
- 48h not measured
- Irritation parameter:
- edema score
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Remarks:
- 48h not measured
- Irritant / corrosive response data:
- The skin reactions observed after 24 hours consisted of well-defined to moderate erythema, very slight to distinct ischemia and very slight or slight edema.
The skin reactions observed after 72 hours consisted of slight to moderate erythema, slight ischemia, slight or distinct scaliness and very slight or slight edema.
There were no distinct differences between skin reactions of the intact skin and those of the abraded skin. - Other effects:
- Gross examination at autopsy showed abnormalities in the mid and high dose groups.
Mid dose one female had haemorrhages in the pancreas and a pale heart.
In the high dose group one male and one female had pale kidneys. This female also showed petachiae in the stomach.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- From the present results it can be concluded that Dupical is a severe primary skin irritant and that it is practically non-toxic when it is applied dermally in one single dose.
- Executive summary:
The product Dupical was examined for primary skin irritating properties and acute dermal toxicity in experiments with albino rabbits.
Dupical was found to be a severe primary skin irritant.
The dermal LD50 of Dupical was found to be between 2.8 and 5.6 ml/kg body weight, suggesting it to be practically non-toxic in the case of one single dermal application.
Dermal application of Dupical at dose leels of 0.0 (control), 1.4, 2.8 and 5.6 ml/kg body weight caused moderate skin reactions at 1.4 ml/kg and moderate to severe skin reactions at 2.8 and 5.6 ml/kg, apathy at 2.8 and 5.6 ml/kg and paresis and/or paralysis at 5.6 ml/kg. Mortality amounted to 25% at 2.8 ml/kg and to 75% at 5.6 ml/kg.
The results on growth rate, food and water intake and haematology did not show toxicologically significant differences between test groups and controls.
Microscopic examination conducted terminally revealed treatment-related changes in the skin only.
It was concluded that Dupical is a severe primary skin irritant and that it is practically non-toxic when it is applied dermally in one single dose.
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