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Diss Factsheets
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EC number: 431-460-4 | CAS number: 10061-02-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 431-460-4
- EC Name:
- -
- Cas Number:
- 10061-02-6
- Molecular formula:
- C3H4Cl2
- IUPAC Name:
- (1E)-1,3-dichloroprop-1-ene
- Test material form:
- liquid
- Details on test material:
- Batch no: TR 88001
Also know as ST088/098
Constituent 1
Test animals
- Species:
- other: rat, Fischer 344
Administration / exposure
- Vehicle:
- other: No vehicle.
- No. of animals per sex per dose:
- 5
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 94 mg/kg bw
- 95% CL:
- 82 - 108
- Remarks on result:
- other: Slope of the mortality curve: 6.8
- Mortality:
- Male: 75 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 90 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 120 mg/kg bw; Number of animals: 5; Number of deaths: 4
Male: 160 mg/kg bw; Number of animals: 5; Number of deaths: 5
Female: 75 mg/kg bw; Number of animals: 5; Number of deaths: 2
Female: 90 mg/kg bw; Number of animals: 5; Number of deaths: 4
Female: 120 mg/kg bw; Number of animals: 5; Number of deaths: 4
Female: 160 mg/kg bw; Number of animals: 5; Number of deaths: 5 - Clinical signs:
- other: Signs of toxicity related to dose levels: The principle signs of reaction to treatment were diarrhoea or voiding of soft faeces, cyanosis, increased lachrymation, a hunched posture, lethargy, piloerection and ante-mortem prostration. Other clinical si
- Gross pathology:
- Effects on organs:
Necropsy of decedents revealed similar abnormalities at each
dose level. Common pathological changes included
discoloration of the renal medulla, congestions of the
lungs, darkening of the liver, the presence of dark or light
patches on the liver, exaggeration of the hepatic lobular
pattern, petechiae on thymus and liquid contents and/or
inflammation of the stomach. Other isolated findings
included heamorrhage of the stomach, heamorrhage or
inflammation of the caecuum, pallor of the spleen and pale,
raised areas on the kidneys.
Any other information on results incl. tables
Migrated information
On the basis of the test results given below and in conformity with the criteria given in Annex VI of the Directive, the substance should be classified as: toxic X
Criteria used for interpretation of results: EU
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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