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Diss Factsheets

Physical & Chemical properties

Water solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods
Justification for type of information:
Experimental result using standard methods of analysis
Qualifier:
according to guideline
Guideline:
other: refer below principle
Principles of method if other than guideline:
The water solubility determination of test item Tripiperazine dicitrate (CAS No; 144-29-6) was done as per the Shake flask method.
GLP compliance:
no
Type of method:
other: shake flask method
Specific details on test material used for the study:
- Name of test material (as cited in study report): Piperazine citrate / tripiperazine dicitrate- Molecular formula: C12H30N6•Cl2H16O14 - Molecular weight: 642.76 g/mole - Substance type: Organic - Physical state: Solid
Key result
Water solubility:
540 g/L
Temp.:
24 °C
pH:
5.6
Remarks on result:
other: no additional details mentioned

TEST DESCRIPTION AND RESULT

Quantity of the Test Test item

(g/ml)

 

Volume of water to be added

(mL)

Temperature at which the testing performed

(°C)

Procedures undertaken

Water solubility Value / Range

(in g/L)

pH of test solution

 

 

56.100 g

 

 

100 ml

 

 

24 °C

Mechanical Stirring

 01 Hrs

 

540 g/L

 

      5.60

Membrane Filtration

Yes performed

 

Air Drying

For 2 hrs
Conclusions:
The water solubility determination of test item Tripiperazine dicitrate (CAS No. 144-29-6) was done gravimetrically as per the shake flask method using membrane filtration assembly. The solubility was determined to be 540 g/L at 24°C.
Executive summary:

The water solubility determination of test item Tripiperazine dicitrate(CAS No. 144-29-6) was done as per the shake flask method. The solubility of Tripiperazine dicitrate in water was determined to be 540 g/L at 24 °C. This value indicates that the substance is very soluble in water.

Description of key information

The water solubility determination of test item Tripiperazine dicitrate (CAS No. 144-29-6) was done gravimetrically as per the shake flask method using membrane filtration assembly. The solubility was determined to be 540 g/L at 24°C.

Key value for chemical safety assessment

Water solubility:
54 000 mg/L
at the temperature of:
24 °C

Additional information

The water solubility determination of test item Tripiperazine dicitrate (CAS No. 144-29-6) was done as per the shake flask method. The solubility of Tripiperazine dicitrate in water was determined to be 540 g/L at 24 °C. This value indicates that the substance is very soluble in water.

Other supporting data from different handbooks also suggest Tripiperazine dicitrate to be very soluble in water.