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EC number: 500-005-2 | CAS number: 9003-35-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data from authoritative database
Data source
Referenceopen allclose all
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity study in Rat for test chemical
- Author:
- U.S .National library of medicine
- Year:
- 2 017
- Bibliographic source:
- ChemID plus A TOXNET DATABASE.2017
- Reference Type:
- secondary source
- Title:
- Acute biological studies on range oftest chemical
- Author:
- NTRL
- Year:
- 1 992
- Bibliographic source:
- National Technical Information Service
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute dermal toxicity study of test chemical was performed in rats
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- yes
Test material
- Reference substance name:
- Formaldehyde, oligomeric reaction products with phenol
- EC Number:
- 500-005-2
- EC Name:
- Formaldehyde, oligomeric reaction products with phenol
- Cas Number:
- 9003-35-4
- Molecular formula:
- (C6H6O.CH2O)x
- IUPAC Name:
- Formaldehyde, oligomeric reaction products with phenol
- Details on test material:
- - Name of test material (as cited in study report): Phenol-formaldehyde resin
- Molecular formula: C6H6O.CH2O)x-
- Molecular weight: 34.133 g/mol
- Substance type: organic
- Physical state: solid
- Smiles notation: c1(c(c(ccc1)[CH])O)O[CH]
- InChl: 1S/C8H6O2/c1-6-4-3-5-7(10-2)8(6)9/h1-5,9H
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- No data available
- Duration of exposure:
- 24hr
- Doses:
- As mentioned in table below
- No. of animals per sex per dose:
- Total :10
male:5
female:5 - Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: No data available
- Necropsy of survivors performed: No data available
- Other examinations performed: clinical signs, body weight, histopathology were observed
other: To prevent the animals from gaining access to the sites of application (and hence
Probably ingesting the test material) acetate collars were placed around each rat's neck for a further 24 hours. - Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was not observed at given dose
- Mortality:
- Mortality observed only for test chemical In IHS (7. 5%).
At 2000 mg/kg- 3/10
At 2500 mg/kg - 9/10
At 3000 mg/kg - 9/10
At 4000 mg/kg - 10/10 - Clinical signs:
- other: As mentioned in table below
- Gross pathology:
- No data available
- Other findings:
- No data available
Any other information on results incl. tables
SR.NO |
Resin type |
Clinical signs |
1 |
Unground Phenol Formaldehyde resol |
Slight sedation and ruffled fur. Mild redness swelling on test site. |
2 |
Resorcinol Phenol Formaldehyde Novolak In IHS (7. 5%) |
Sedation and ruffled fur. mild redness swelling on test site |
3 |
Phenol Formaldehyde Resol In Ethanol (43%) |
Nothing abnormal detected |
4 |
Phenol Formaldehyde Resol In IHS (19. 7%) |
Slight sedation and ruffled fur. and curved posture |
5 |
Phenol Formaldehyde liquid Resol |
Sedation and ruffled fur. mild redness swelling on test site |
6 |
Phenol Formaldehyde liquid Resol |
Nothing abnormal detected. Skin stained at test site |
7 |
Water Dilutable Phenol Formaldehyde Liquid Resol |
Nothing abnormal detected. Well depend redness on test site on female animals for 24 hrs following patches removal. |
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The LD50 value was considered to be >2000mg/kg bw, when rats were treated with test chemical by dermal application
- Executive summary:
Acute dermal toxicity test was carried out for different grades of test chemical. Groups of five male and five female rats were exposed to single doses of selected resin applied to the skin under occlusion for 24 hours.A similar group, exposed to the patches alone, served as controls.The animals were observed for 14 days following exposure for signs of toxicity.No fatalities occurred, except at the higher treatment levels with test chemical in ethanol containing 23% free phenol, during the observation period although evidence of irritancy was noted with certain grades. Bodyweight gain was essentially similar in treated and control animals and no significant macroscopic changes were seen in the organs at autopsy.Dermal LD values for all the grades examined under the conditions of exposure, considered to exceed 2000 mg/kg. Hence, The LD50 value was considered to be >2000mg/kg bw, when rats were treated with test chemical by dermal application.
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