Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 418-200-5 | CAS number: 69227-51-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July-December 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study done under GLP and OECD guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 1-ethyl-1-methylpyrrolidinium bromide
- EC Number:
- 418-200-5
- EC Name:
- 1-ethyl-1-methylpyrrolidinium bromide
- Cas Number:
- 69227-51-6
- Molecular formula:
- C7H16NBr
- IUPAC Name:
- 1-ethyl-1-methylpyrrolidin-1-ium bromide
Constituent 1
- Specific details on test material used for the study:
- Cas # 69227-51-6
Batch # 0691
pH: 6-9
Storage: 5°C in the dark
Supplier: Chemson, Polymer-Additive Gesellschaft m.b.H. A-9601 Arnoldstein.
Characterization:
Appearance: Colorless liquid.
pH 6.84
Content 52.2% (estimation of bromide)
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Remarks:
- Him: OFA
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Supplier: Forscungsinstitute fur Versuchstierzucht, A-2325 Himbera.
Number in the study: 5 males and 5 females
Age: approx. 8 weeks (males) and 12 weeks (females) at time of administration.
Body weight: 245 gr (mean, males), 230 (mean, females)
Hygiene: imporoved conventional conditions
room temperature: average of 12 °C.
Relative humidity: average of 55%
Air exchange 12 / h
Light: artificial light from 6 am to 6 pm
Cages: single caging in Makrolon cages type III . Wire mesh lids.
Bedding material: Aspen wood chips, autoclaved
Feed: Altromin No. 1314 ff, gamma irradiated with 10 kGy 60Co, ad libitum.
Water: tap water, offered in Makrolon bottles with stainless steel canules, ad libitum.
Acclimatization: 7 days
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Dermal administration was performed once in the morning by spreading the test substance over an area of approx. 5 cm x 6 cm which is at least 10% of the body surface.
Hair was clipped one day before the application with an electric hair clipper. The test site was median on the dorsal thoracal region.
The administrated test substance was covered by cellulose patch and held in place by non irritating tape. Patch and tape were covered by a dressing. - Duration of exposure:
- The duration of the exposure was 24 hr
At the end of the exposure period the dressing the tape and the patch were removed. residual test substance was wiped off using wet cellulose tissue. - Doses:
- 2000 mg/kg b.w
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- Behaviour, reactions and physical signs of the animals were observed 10, 30 min, 1, 2, 4 and 6 hr after administration (p.a) and then at least once a day for a total of 2 weeks. Body weight was determined before administration, 7 days p.a. and 14 days p.a.
All animles were sacrificed by CO23 14 days p.a. and examined macroscopically in an attempt to detect possible residual lesions.
- Statistics:
- n/a
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No mortality
- Body weight:
- Body weight and body weight gain were inconspicuous in all males and in 2/5 females. In the other females a body weight loss respectively a lower body weight gain as compared to untreated animals of the same strain were noted.
- Other findings:
- 3/10 animls were normal during the whole observation time. All males and 2/5 females chromodacryorrhoea, a sign of general malase, was observed within maximium 4 hr p.a. and is attributed to a reduced wellbeing caused by the dressing. Salivation, noted in one male, is not regarded as important due to single and short occurrence.
8/10 animles were normal at terminal necropsy.
A large spleen, noted in two females, is regarded as incidental finding without toxicological importance.
No sex diffences were noted except for body weight gain which was lowered in some females.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- All animles survived until termination.
No toxicological signs were observed during the test and obervations which were noted were not of toxicological importance.
Therefore LD50 of the test substance was > 2000 mg/kg b.w - Executive summary:
A 50% solution of the test substance was administered once dermally to 5 males and 5 females (Him:OFA rats) (OECD 402).
The test substance was applied at a dose of 2000 mg/kg. the duration of the exposure was 24 hr and the study terminated after 14 days.
All animals survuved until the end of the study.
No toxicological signs were observed during the test and obervations which were noted were not of toxicological importance.
Therefore LD50 of the test substance was > 2000 mg/kg b.w
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.