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Diss Factsheets
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EC number: 214-968-9 | CAS number: 1229-55-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- data is from peer-reviewed journal
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Acute Toxicity Evaluation of Solvent Red 1
- Author:
- Gunda Reddy and Dale A. Mayhew
- Year:
- 1 996
- Bibliographic source:
- International Journal of Toxicology Vol 15, Issue 1_suppl, pp. S43 - S44, 1996
- Reference Type:
- secondary source
- Title:
- Dermal, Eye and Oral toxicological evaluations, phase IV report with Disperse Red 11, Disperse Blue 3, Solvent Red 1 and Red and Violet Mixtures.
- Author:
- U.S. Army Medical Bioengineering Research and development Laboratory
- Year:
- 1 986
- Bibliographic source:
- NTRL- April - 1986, Page no 1-169.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity study of Solvent Red 1 in rat.
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 1-[(2-methoxyphenyl)azo]-2-naphthol
- EC Number:
- 214-968-9
- EC Name:
- 1-[(2-methoxyphenyl)azo]-2-naphthol
- Cas Number:
- 1229-55-6
- Molecular formula:
- C17H14N2O2
- IUPAC Name:
- 1-[(2-methoxyphenyl)azo]-2-naphthol
- Details on test material:
- - Name of test material (as cited in study report): Solvent Red 1
- Molecular formula (if other than submission substance): C17H14N2O2
- Molecular weight (if other than submission substance): 278.31 g/mole
- Substance type: Organic
- Physical state: Solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Solvent Red 1
- Molecular formula (if other than submission substance): C17H14N2O2
- Molecular weight (if other than submission substance): 278.31 g/mole
- Substance type: Organic
- Physical state: Solid
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Details on test animal
TEST ANIMALS
- Source: Charies river breeding laboratories, IC (postage NY, facility)
- Age at study initiation: No data available
- Weight at study initiation: 208-221 g male, 174-183 g female.
- Fasting period before study: Yes, fasted overnight.
- Housing: Animals were housed in the appropriate randomly selected cage. Each animal was then assigned a sequential animal number unique within American Biogenics Corporation (ABC) and identified with an ear tag bearing this animal number, The sequential animal number was listed on a cage card that was affixed to the front of the animal's cage. Rooms were cleaned daily and the cages were cleaned and sanitized as specified in ABC SOP's. Urine and feces fell through the wire mesh floor onto animal caging board. The cage boards were changed at least 2 to 3 times per week.
- Diet (e.g. ad libitum): Purina Certified Rodent Chow 5002, ad libitum, except for fasting prior to dosing.
- Water (e.g. ad libitum): Filtered tap water was provided through an automatic watering system and was analyzed periodically, ad libitum.
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 7 °C
- Humidity (%): 30-70 %
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): 6:00 a.m. to 6:00 p.m. (12 hour light/dark, cycle)
IN-LIFE DATES:
From: October 30, 1985
To: November 13, 1985
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- Details on exposure
VEHICLE
- Concentration in vehicle: 5000 mg/kg bw
- Amount of vehicle (if gavage): 28 mllkg
- Justification for choice of vehicle: com oil
- Lot/batch no. (if required): No data available
- Purity: No data available
MAXIMUM DOSE VOLUME APPLIED: No data available
DOSAGE PREPARATION (if unusual): Solvent Red 1 was suspended in 18 % weight/volume corn oil in two doses and then administered.
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: No data available
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- Total:10
5 male , 5 female - Control animals:
- not specified
- Details on study design:
- Details on study design
- Duration of observation period following administration: 14 days (or other?): 14 days
- Frequency of observations and weighing: on day 0 and daily thereafter.
- Necropsy of survivors performed: Yes
- Other examinations performed: clinical signs, body weight, organ weights, histopathology, other: Yes, clinical signs, body weight and histopathology were performed. - Statistics:
- The mean, standard deviation, and standard error were calculated for the body weight data and for the amount of test article administered.
For oral LD50 value, the 95 percent confidence interval, the slope of the dose-response curve, and correction factors for 0 and 100 percent observed responses were calculated by computer program employing the methodology of Litchfield and Wilcoxon.
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality observed
- Mortality:
- No mortality was observed in treated rat at 5000 mg/kg bw
- Clinical signs:
- other: Red colored urine and stool; loose stool; red stained fur in the perianal region, on the head and ventral portion of the body, on the muzzle and red colored stain on the tail of treated rat
- Gross pathology:
- No gross pathological abnormal findings were observed in treated rat.
- Other findings:
- Red colored urine and stool; loose stool was observed in treated rat.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was considered to be > 5000 mg/kg bw when Fischer 344 male and female rats were treated Solvent Red 1 (manganese(2+) bis(phosphinate)) orally.
- Executive summary:
In acute oral toxicity study, Fischer 344 male and female rats were treated Solvent Red 1 (manganese(2+) bis(phosphinate)) in the concentration of 5000 mg/kg bw in corn oil orally by gavage. No mortality was observed in treated rat at 5000 mg/kg bw. Red colored urine and stool; loose stool; red stained fur in the perianal region, on the head and ventral portion of the body, on the muzzle and red colored stain on the tail of treated rat. Overall body weight gain was observed in treated rat. No gross pathological abnormal findings were observed in treated rat. Therefore, LD50 was considered to be > 5000 mg/kg bw when Fischer 344 male and female rats were treated Solvent Red 1 (manganese(2+) bis(phosphinate)) orally.
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