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EC number: 457-690-5 | CAS number: 23432-65-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 Jul - 20 Aug 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Hessisches Ministerium für Umwelt, Landwirtschaft und Forsten
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: Domestic sewage treatment plant Groß-Zimmern, Germany
- Laboratory culture: no
- Preparation of inoculum for exposure: The activated sludge was washed by centrifugation and the supernatant liquid phase was decanted. The solid material was resuspended in tap water and again centrifuged. This procedure was repeated twice. An aliquot of the final sludge suspension was weighed, dried and the ratio of the wet sludge to its dry weight was determined. Based on this ratio, calculated aliquots of washed sludge suspension, corresponding to 1.5 g dry material/L were mixed with test water and then aerated until use.
- Concentration of sludge: 30 mg suspended solids/L
- Water filtered: no - Duration of test (contact time):
- 28 d
- Initial conc.:
- 25.5 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: according to guideline with deionised water
- Test temperature: 21 - 22 °C
- pH: 7.6 (measured at start); 7.6 - 7.9 (end of the test)
- Suspended solids concentration: 30 mg/L
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: Manometric Test System with test flaskscontaining a volume of 500 mL in a climate chamber.
- Measuring equipment: The change of pressure in the test flasks was measured by means of a Manometric method (BSB/BOD-Sensor-System, Aqualytic, Neu Isenburg, Germany) each day.
- Method used to create aerobic conditions: continuous stirring
- Details of trap for CO2 and volatile organics if used: Evolved CO2 was absorbed in an aqueous solution (45%) of potassium
- Test performed in closed vessels due to significant volatility of test substance: no
SAMPLING
- Sampling frequency: O2 concentration was measured each day
- Sampling method: Manometric method (BSB/BOD-Sensor-System, Aqualytic, Neu Isenburg, Germany)
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes, 2 replicates
- Abiotic sterile control: yes, 2 replicate
- Toxicity control: yes, 1 replicate
- Reference substance: yes, 1 replicate - Reference substance:
- aniline
- Parameter:
- % degradation (O2 consumption)
- Value:
- 19.5
- Sampling time:
- 28 d
- Remarks on result:
- other: Mean of two replicates based on ThOD NH4
- Parameter:
- % degradation (O2 consumption)
- Value:
- 15.5
- Sampling time:
- 28 d
- Remarks on result:
- other: Mean of two replicates based on ThOD NO3
- Results with reference substance:
- 82% after 14 d based on ThOD NH4 60% pass level was reached.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- A biodegradation result of 19.5% in 28 days (ThOD) was determined in a reliable study conducted according to an appropriate test protocol, and in compliance with GLP.
Reference
The toxicity control attained 56% degradation after 14 d. Thus, the test substance is not inhibitory to the inoculum. In the abiotic control, no oxygen demand was determined.
Table 1: Percentage biodegradation (BOD/ThOD NH4) of test item, of aniline and of the toxicity control
Time [d] |
Percentage biodegradation |
|||
Test substance |
Aniline |
Toxicity control |
||
Flask 1 |
Flask 2 |
|||
1 |
-2 |
-2 |
-1 |
-1 |
2 |
7 |
4 |
-2 |
5 |
3 |
7 |
5 |
-3 |
7 |
4 |
11 |
9 |
6 |
43 |
5 |
15 |
13 |
58 |
45 |
6 |
15 |
13 |
61 |
47 |
7 |
17 |
14 |
65 |
49 |
8 |
23 |
20 |
71 |
51 |
9 |
23 |
20 |
74 |
52 |
10 |
23 |
21 |
78 |
53 |
11 |
26 |
23 |
80 |
53 |
12 |
26 |
23 |
82 |
54 |
13 |
27 |
24 |
81 |
55 |
14 |
26 |
22 |
82 |
56 |
15 |
26 |
23 |
82 |
57 |
16 |
25 |
23 |
84 |
58 |
17 |
26 |
24 |
84 |
58 |
18 |
26 |
23 |
84 |
58 |
19 |
24 |
21 |
85 |
59 |
20 |
23 |
21 |
84 |
58 |
21 |
23 |
23 |
86 |
58 |
22 |
23 |
23 |
86 |
60 |
23 |
23 |
23 |
90 |
60 |
24 |
23 |
23 |
92 |
60 |
25 |
23 |
21 |
93 |
59 |
26 |
21 |
20 |
92 |
58 |
27 |
22 |
21 |
94 |
58 |
28 |
20 |
19 |
94 |
58 |
Description of key information
Not readily biodegradable: 15.5 - 19.5% after 28 d (O2 consumption, OECD 301 F, EU C.4-D)
Key value for chemical safety assessment
- Biodegradation in water:
- not biodegradable
- Type of water:
- freshwater
Additional information
The target substance methyl-N-{[dimethoxy(methyl)silyl]methyl}carbamate (CAS 23432-65-7) hydrolyses within the timescale of a ready biodegradation test to form methyl-N-{[dihydroxy(methyl)silyl]methyl}carbamate and methanol (DT50 = 1.9 h at pH 7 and 20 - 25 °C).
The available study investigating the ready biodegradability of methyl-N-{[dimethoxy(methyl)silyl]methyl}carbamate (CAS 23432-65-7) was performed according to OECD guideline 301 F and under GLP conditions. The inoculum (non-adapted activated sludge from a sewage treatment plant) was exposed for 28 days to the test substance and biodegradation was calculated based on O2 consumption. A biodegradation of 15.5 - 19.5% (O2 consumption) was recorded after the exposure period. Thus, the substance is not readily biodegradable according to OECD criteria. Because the substance hydrolyses rapidly in contact with water (DT50: 1.9 h at 20 - 25 °C, pH 7), the result from this study mainly reflects the biotic degradation of the hydrolysis products. The alcohol hydrolysis product methanol is known to be readily biodegradable (OECD SIDS, 2004). Thus, the final result is mainly attributed to the silanol hydrolysis product methyl-N-{[dihydroxy(methyl)silyl]methyl}carbamate which is considered not to be readily biodegradable according to the OECD criteria based on the results of the study.
References:
OECD SIDS, 2004: SIDS Initial Assessment Report for Methanol, SIAM 19, Berlin, Germany, 19-22 October 2004, Methanol, CAS 67-56-1
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