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EC number: 204-185-0 | CAS number: 117-34-0
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic / sediment
From BCFBAF (v3.00) model of EPI suite and PBT profiler the estimated bio concentration factor (BCF) for 1,1-Diphenylacetic acid is 3.2 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000.Thus it is concluded that 1,1-Diphenylacetic acid is not expected to bio accumulate in the aquatic environment.
Additional information
Bioaccumulation: aquatic / sediment
Four studies including predicted data from validated models and experimental data from authorative database for bioaccumulation (BCF) endpoint of target chemical 1,1-Diphenylacetic acid (Cas no. 117-34-0) with relevant read across which is structurally similar to target were summarized as follows:
First study from prediction done using BCFBAF (v3.00) model and PBT profiler which indicate the estimated bio concentration factor (BCF) for 1,1-Diphenylacetic acid is 3.2 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000.Thus it is concluded that 1,1-Diphenylacetic acid is not expected to bio accumulate in the aquatic environment.
Above prediction is supported by data Scifinder database which suggest the Bioconcentration factor (BCF) for target chemical 1,1-Diphenylacetic acid was predicted to be 66.9 at pH 1, 66.8 at pH 2, 65.7 at pH 3, 56.2 at pH 4, 23.0 at pH 5, 3.35 at pH 6, 1.0 at pH range 7-10 and temperature 25 deg.C.Based on the BCF concentration at all range of pH it is concluded that the test chemical 1,1-Diphenylacetic acid is non bioaccumulative in nature as it does not exceed the BCF criteria of 2000.
Another estimation from Chemspider - ACD/PhysChem Suite indicate the Bioconcentration factor (BCF) for target chemical 1,1-Diphenylacetic acid was estimated to be 33.76 at pH 5.5 and 1.00 at pH 7.4 at temperature 25 deg.C.Based on the BCF concentration at two different pH concluded that the test chemical 1,1-Diphenylacetic acid is non bioaccumulative in nature as it does not exceed the BCF criteria of 2000.
Above all results for target are further supported by experimental data of read across chemical nicotinic acid (Cas no. 59-67-6) which suggest an estimated BCF value of 3 was calculated in fish for nicotinic acid, using a log Kow of 0.36 and a recommended regression derived equation. This BCF value suggests that the potential for bioconcentration in aquatic organisms (fish) is low. (HSDB database by US EPA; 2017)
Thus based on all available studies for bioaccumulation endpoint concluded that the test substance 1,1-Diphenylacetic acid (Cas no. 117-34-0) is expected to be non Bioaccumulative in aquatic environment.
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