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EC number: 246-613-9 | CAS number: 25103-09-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- Isooctyl mercaptoacetate
- EC Number:
- 246-613-9
- EC Name:
- Isooctyl mercaptoacetate
- Cas Number:
- 25103-09-7
- Molecular formula:
- C10H20O2S
- IUPAC Name:
- 2-methylheptyl 2-sulfanylacetate
- Details on test material:
- Identification: Isooctyl thioglycolate (IOTG)
CAS no. 25103-09-7
Purity >98%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- Groups of 10 male and 10 female rats were exposed to 0, 1.6 or 3.2 ppm IOTG vapor for 6 hours/day, 5 days/week for 10 exposures. Vapors of IOTG were generated by counter-current exchange between air and liquid IOTG at room temperature in a 15-plate perforated plate distillation column.
Feed and water were removed during the exposure period (including controls) but were available ad libitum at all other times. - Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- Analytical concentrations of IOTG vapor in the exposure chambers were determined by gas chromatography.
- Duration of treatment / exposure:
- 2 weeks
- Frequency of treatment:
- 6 hrs/day, 5 days/week (10 exposures)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1.6 or 3.2 ppm (0.19 or 0.38 mg/m3)
Basis:
- No. of animals per sex per dose:
- 10
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Post-exposure period: none
Examinations
- Observations and examinations performed and frequency:
- All animals were weighed on exposure days 0, 3, 6, 8 and 10. The rats were observed during each exposure day for signs of toxicity and changes in appearance and demeanor. After 9 days of exposure, basic hematology and urinalysis studies were conducted on 7 rats/sex/group. Hematological parameters included red blood cell counts, total and differential white blood cell counts, hemoglobin concentrations and packed cell volume. Blood for hematology was obtained from the tail veins. Urinalysis included the determination of pH, specific gravity, glucose, ketones, bilirubin, occult blood, urobilinogen and protein in the urine. At necropsy, clincial chemistry determinations of blood urea nitrogen (BUN), serum glutamic pyruvic transaminase (SGPT), serum alkaline phosphatase, and serum glucose levels were done on 7 rats/sex/group. Blood for clinical chemistry tests were obtained from the cervical vessels.
- Sacrifice and pathology:
- Gross necropsy was conducted on all rats. Prior to necropsy, the rats were fasted overnight, weighed, anesthetized with methoxyfluorane to facilitate the clamping of the trachea, and than killed by decapitation. The lungs and trachea were removed as a unit and expanded by a hand syringe with 10% formalin. Body weights and organ weights for liver, kidneys, brain, heart thymus and testes were obtained from all rats at necropsy. Organs to body weight ratios were calculated. Histopathology was not performed on any of the treated animals.
- Statistics:
- Hematology, urinalysis, clinical chemistry, organ and body weight data were analyzed using an analysis of variance and Dunnett's test (Steela nd Torrie, 1960.) The level of significance in all cases was p<0.05.
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- no effects observed
- Clinical biochemistry findings:
- no effects observed
- Urinalysis findings:
- no effects observed
- Behaviour (functional findings):
- not examined
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- not examined
- Histopathological findings: neoplastic:
- not examined
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 3.2 ppm
- Sex:
- male/female
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Mean analytical concentrations for the 10 exposures were 1.6
(SD = 0.6) ppm and 3.2 (SD = 2.3) ppm. No clinical signs of
irritation or toxicity were seen in any exposed male or
female rats throughout the study. All male and female
exposed rats had weight gain comparable to male and female
control rats. There were no exposure-related effects on
hematology, urinalysis, clinical chemistry, organ and
terminal body weights for male and female rats. There were
no exposure-related lesions observed in any rats at
necropsy. Histopathology was not performed on any of the
treated animals.
Applicant's summary and conclusion
- Executive summary:
Groups of 10 Sprague-Dawley rats/sex were exposed to 0, 1.6 or 3.2 ppm (0, 0.19 or 0.38 mg/m3) IOTG vapor for 6 hours/day, 5 days/week for 10 exposures (Yakel and Kociba, 1979). Vapors of IOTG were generated by counter-current exchange between air and liquid IOTG at room temperature in a 15-plate perforated plate distillation column. Analytical concentrations of IOTG vapor in the exposure chambers were determined by gas chromatography. All animals were weighed on exposure days 0, 3, 6, 8 and 10. The rats were observed during each exposure day for signs of toxicity and changes in appearance and demeanor. After 9 days of exposure, basic hematology and urinalysis studies were conducted on 7 rats/sex/group. At necropsy, clinical chemistry determinations were performed on 7 rats/sex/group. Gross necropsy was conducted on all rats. Body weights and organ weights were obtained from all rats at necropsy. Histopathology was not performed on any of the treated animals. Mean analytical concentrations for the 10 exposures were 1.6 (SD = 0.6) ppm and 3.2 (SD = 2.3) ppm. No clinical signs of irritation or toxicity were seen in any exposed rats throughout the study. All exposed rats had weight gain comparable to control rats. There were no exposure-related effects on hematology, urinalysis, clinical chemistry, organ and terminal body weights for male and female rats. There were no exposure-related lesions observed in any rats at necropsy. The NOAEL was 3.2 ppm.
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