Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-806-9 | CAS number: 697-82-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
An experimental study conducted by Tetsuo Yamano et al.( Toxicology , 2007) on target substance2,3,5 trimethylphenols (697-82-5) on mice. LLNA test was conducted on male BALB/cA mice for 2,3,5 trimethylphenols (697-82-5) . On 3 consecutive days the groups of 3 mice were exposed to at 25 µl of 1M of chemical. Acetone/ olive oil, 4:1 were used as a vehicle. Three or five days after the last application, a pair of auricular lymph nodes (LNs) from each mouse was excised for the LLNA. A stimulation index was calculated as the ratio of the BrdU amount in the lymph nodes of chemical-treated mice to that of vehicle-treated mice. Stimulation index variation was observed as 0 for the test chemical.From experiment it was concluded that the 2,3,5Trimethylphenol (697-82-5) was considered to be non-sensitizing in mice LLNA assay.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Data is from publication.
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Mouse local lymphnode assay (LLNA) was used to determined skin sensitization potential of 2,3,5Trimethylphenol in mice.
- GLP compliance:
- not specified
- Type of study:
- mouse local lymph node assay (LLNA)
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 2,3,5Trimethylphenol
- Molecular formula (if other than submission substance): C9H12O
- Molecular weight (if other than submission substance): 136.193 g/mol
- Substance type: Organic
- Physical state: Solid - Species:
- mouse
- Strain:
- other: BALB/cA mice
- Sex:
- male
- Details on test animals and environmental conditions:
- Details on test animal
TEST ANIMALS
- Source: CLEA Japan (Tokyo, Japan)
- Age at study initiation: Six- to eight-week-old
- Weight at study initiation: No data available
- Housing: No data available
- Diet (e.g. ad libitum): No data available
- Water (e.g. ad libitum): No data available
- Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%):No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available - Vehicle:
- other: acetone/ olive oil, 4:1, AOO
- Concentration:
- 25 µl of 1M of 2,3,5 trimethylphenols
- No. of animals per dose:
- 3 mice
- Details on study design:
- TREATMENT PREPARATION AND ADMINISTRATION: Groups of three mice were exposed to 25 µl of 1M methylphenols, 0.3% DNCB, 3% TMA, or vehicle (acetone/ olive oil, 4:1, AOO) through application to the dorsum of both ears for 3 consecutive days. Three or five days after the last application, a pair of auricular lymph nodes (LNs) from each mouse was excised for the LLNA
- Positive control substance(s):
- not specified
- Statistics:
- The values for each chemical-treated group and vehicle group (control group) were compared via Dunnett’s or Steel’s multiple comparison method using a StatLight software package
In stimulation index was calculated as the ratio of the BrdU amount in the lymph nodes of chemical-treated mice to that of vehicle-treated mice. - Key result
- Parameter:
- SI
- Value:
- 0 - 0
- Variability:
- 1-12
- Test group / Remarks:
- Stimulation index result was zero for the test group.
- Remarks on result:
- other: No indication of skin sensitization .
- Cellular proliferation data / Observations:
- Yes
- Interpretation of results:
- other: not sensitizing
- Conclusions:
- Skin sensitization test was observed for 2,3,5 trimethylphenols (697-82-5) in BALB/cA mice by LLNA method.The test result for 2,3,5Trimethylphenol (697-82-5) was in LLNA assay.
- Executive summary:
LLNA test was conducted on male BALB/cA mice for 2,3,5 trimethylphenols (697-82-5) . On 3 consecutive days the groups of 3 mice were exposed to at 25 µl of 1M of chemical. Acetone/ olive oil, 4:1 were used as a vehicle. Three or five days after the last application, a pair of auricular lymph nodes (LNs) from each mouse was excised for the LLNA. A stimulation index was calculated as the ratio of the BrdU amount in the lymph nodes of chemical-treated mice to that of vehicle-treated mice. Stimulation index variation was observed as 0 for the test chemical.From experiment it was concluded that the 2,3,5Trimethylphenol (697-82-5) was considered to be non-sensitizing in mice LLNA assay.
Reference
No indication of skin sensitization .
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Skin sensitization
In different studies, 2,3,5 trimethylphenols (697-82-5) has been investigated for potential for dermal sensitization to a greater or lesser extent. The study is based on in vivo experiments in mice by LLNA method for target chemical2,3,5 trimethylphenols (697-82-5). The target experimental data has also been supported with predicted data using the OECD QSAR toolbox.
A key experimental study conducted by Tetsuo Yamano et al.( Toxicology , 2007) on target substance2,3,5 trimethylphenols (697-82-5) on mice. LLNA test was conducted on male BALB/cA mice for 2,3,5 trimethylphenols (697-82-5) . On 3 consecutive days the groups of 3 mice were exposed to at 25 µl of 1M of chemical. Acetone/ olive oil, 4:1 were used as a vehicle. Three or five days after the last application, a pair of auricular lymph nodes (LNs) from each mouse was excised for the LLNA. A stimulation index was calculated as the ratio of the BrdU amount in the lymph nodes of chemical-treated mice to that of vehicle-treated mice. Stimulation index variation was observed as 0 for the test chemical.From experiment it was concluded that the 2,3,5Trimethylphenol (697-82-5) was considered to be non-sensitizing in mice LLNA assay.
The skin sensitization potential of 2,3,5 trimethylphenols (697-82-5) was estimated by SSS (2017) using OECD QSAR toolbox v3.3 with log kow as the primary descriptor and considering the six closest read across substances. 2,3,5 trimethylphenols (697-82-5) was predicted to be non sensitizing to the skin of Hartley strain and Hartley-English short hair cross-strain guinea pig.
Thus based on the experimental study and prediction on 2,3,5 trimethylphenols (697-82-5) , it can be concluded that 2,3,5 trimethylphenols is not a skin sensitizer. Thus comparing the above annotations with the criteria of CLP regulation, 2,3,5 trimethylphenols (697-82-5) can be considered as not classified for skin sensitization effects.
Justification for classification or non-classification
Thus comparing the above annotations with the criteria of CLP regulation, 2,3,5 trimethylphenols (697-82-5) can be considered as not classified for skin sensitization effects
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.