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EC number: 813-266-5 | CAS number: 45101-66-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Hazard for air
Hazard for terrestrial organisms
Hazard for predators
Additional information
No experimental data for 6-chlorohexyl methacrylate (6-CHMA) is available to assess the environmental fate of this substance. An alert regarding aquatic toxicity classification by ECOSAR for 6-CHMA is raised by OECD QSAR Toolbox based on the substance is a methacrylates.
Some concern for aquatic toxicity of 6-CHMA is expected also based on the similarity with short chain alkyl methacrylates and in particular with 2-ethylhexyl methacrylate CAS 688-84-6 (see document "Read -across hypothesis and justification" in section 13 of this IUCLID dossier). As reported in SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004), the methacrylates esters are of low to high toxicity to aquatic organisms as toxicity increases with increasing lipophilicity and molecular size across the category with ethyl metachacrylates CAS 97-63-2 (EMA) being the least toxic and 2-ethylhexyl methacrylate CAS 688-84-6 (2-EHMA) the most toxic. However, the predicted values by ECOSAR v.1.11 for 2-ethylhexyl methacrylate are more precautionary than the experimental values reported by SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004) and they are similar to the predicted values for 6 -CHMA. For classification purpose regarding aquatic toxicity of 6-chlorohexyl methacrylate the experimental values for similar substance 2-ethylhexyl methacrylate are used based on they are less precautionary but more realistic than ECOSAR prediction for 6-CHMA.
|
Target substance |
Source substance- predicted |
Source substance experimental |
Reference substance |
6-chlorohexyl methacrylate (predicted values, ECOSAR class methacrylates) |
2-ethylhexyl methacrylate (predicted values, ECOSAR class methacrylates)* |
2-ethylhexyl methacrylate (experimental values)** |
Short-term fish |
LC50 96h fish = 1.463 mg/l
|
LC50 96h fish = 0.568 mg/l
|
Oryzias latipes LC50 96h = 2.78 mg/l (OECD203 ref.MoE,1998)
|
Short-term invertebrates |
LC50 48h Daphnid = 1.267 mg/l |
LC50 48h Daphnid = 0.505 mg/l |
Daphnia magna EC50 48h = 4.6 mg/l (OECD 202, ref.MoE,1998)
|
Short-term algae |
EC50 96h green algae = 0.099 mg/l
|
EC50 96h green algae = 0.067 mg/l
|
Selenastrum capricornutum EC 72h growth rate= 7.68 mg/l (OECD 201, ref. MoE,1998)
|
Long-term invertebrates |
ChV Daphnid= 0.141 mg/l (estimated by acute to chronic ratio per method)
|
ChV Daphnid= 0.058 mg/l (estimated by acute to chronic ratio per method) |
NOEC Daphnia magna 21 days = 0.105 mg/l (OECD211, ref.Schäfers,2004) |
*The melting point = - 7.79, Log Kow =4.54 and water solubility = 5.922 mg/l predicted by EPI Suite v.4.1.for CAS 688-84-6 were used by ECOSAR v. 1.11 for the estimation of ecotox properties of 2-ethylhexyl methacrylate
**The experimental values for 2-ethylhexyl methacrylate(2-EHMA) are based on study reported in SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004) inside the specific section of 2-EHMA.
- MoE, Japan, 1998 Ministry of the Environment, unpublished data for 2-Ethylhexyl methacrylate. Note: in this study the concentrations, included EC50, are above the limit of solubility
- Schäfers C.,2004, 2-Ethylhexyl methacrylate: Daphnia magna, reproduction test in closed vessels. Unpublished report no. MPA-001/4-21 on behalf of Methacrylate Producers Association.
The predicted values for 2-ethylhexyl methacrylate are lower than experimental data reported in SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004). Based on the predicted values for 6-chlorohexyl methacrylate (6-CHMA) are higher that the predicted value for 2-ethylhexyl methacrylate (2-EHMA) the experimental data for 2-EHMA can be used for classification purpose of 6-chlorohexyl methacrylate: these data are higher than predicted data for 6-CHMA but are more realistic (see table ABOVE) and this approach is precautionary based on the predicted data for 6-EHMA is lower than predicted data for 6-CHMA.
The similar behaviour of 6-CHMA and 2-EHMA regarding aquatic toxicity reflects their comparable solubility in water, positive logKow, and low potential of bioaccumulation common to both substances.
Based on experimental data available for the similar substance 2-ethylhexyl methacrylate and considering 6-chlorohexyl methacrylate to be ready-biodegradability like all the other short chain alkyl methacrylates, the classification H412 (Chronic aquatic toxicity cat.3) is proposed according to the CLP Regulation (EC n. 1272/2008).
Conclusion on classification
Based on experimental data available for the similar substance 2-ethylhexyl methacrylate (see document "Read -across hypothesis and justification" in section 13 of this IUCLID dossier) and considering 6-chlorohexyl methacrylate to be ready-biodegradability like all the other short chain alkyl methacrylates, the classification H412 (Chronic aquatic toxicity cat.3) is proposed according to the CLP Regulation (EC n. 1272/2008).
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