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EC number: 203-687-7 | CAS number: 109-61-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is comparable to OECD 403 (inhalation risk test) with acceptable restrictions mostly due to reduced reporting in times before GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- other: inhalation risk test
Test material
- Reference substance name:
- Propyl chloroformate
- EC Number:
- 203-687-7
- EC Name:
- Propyl chloroformate
- Cas Number:
- 109-61-5
- Molecular formula:
- C4H7ClO2
- IUPAC Name:
- propyl carbonochloridate
- Details on test material:
- - Name of test material (as cited in study report): n-Propyl-chlorkohlensaeureester
- Physical state: liquid
- Purity: approx. 95%
- Expiration date of the lot/batch: not reported
- Stability under test conditions: not reported
- Storage condition of test material: not reported
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Mean weight at study initiation: males 165 g; females 133 g
no further details given
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- Rats exposed for 3 min, 1 h, respectively, to a vapour saturated atmosphere.
Vapour was generated by bubbling 200 l/h dry air (no CO2) through the liquid substance column (volume ca. 50 ml) of about 5 cm above a fritted glass disc in a glass cylinder. The glass cylinder was heated in a water bath. The air pressure was 754 mm Hg. Temperature in the exposure chamber was 20°C. Concentration was stated in the raw data to be 1.385 mg/L (= 272.5 ppm) in the case of the 3 min exposure and 200 ppm (= ca. 1.091 mg/L) in case of the 1 h exposure.
The vapour saturation treshold is calculated to be approx. 135 mg/L (at 23.3°C). - Analytical verification of test atmosphere concentrations:
- no
- Remarks on duration:
- 3 min or 1 h
- Concentrations:
- 1.385 mg/L in the case of the 3 min exposure; 1.019 mg/L in case of the 1 h exposure.
- No. of animals per sex per dose:
- 6 animals each were treated for 3 min in two trials; 10 animals were treated for 1 h in one trial
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: No weighing was done. Observation was several times at the day of exposure and afterwards presumably daily except on weekends and holidays.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- none
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: IHT
- Remarks on result:
- other: Mortality appeared within 3 min
- Mortality:
- 3 min at 1.385 mg/L: 12/12 animals died within 2 h
1 h at 1.019 mg/L: 3/10 animals died within 6 d - Clinical signs:
- other: 3 min at 1.385 mg/L: Vigorous attempts to escape; extremely severe irritation to the mucosa; gasping breathing 1 h at 1.019 mg/L: Restlessness; irritation to the mucosa; dyspnea
- Body weight:
- Mean body weight after 14 d
1 h at 1.019 mg/L: males 190 g (+25g); females 157 g (+24 g) - Gross pathology:
- 3 min at 1.385 mg/L: Congestion and edema of the Iungs
1 h at 1.019 mg/L: Acute pulmonary emphysema - Other findings:
- 3 min at 1.385 mg/L: A concentration of 40 ppm phosgen was measured above the TS by Draeger tube method pointing to the fact that the TS has partly hydrolised to phosgen.
Applicant's summary and conclusion
- Executive summary:
Study is comparable with the inhalation hazard test described in the Annex of OECD Guideline 403 (adopted 1981) with acceptable restrictions mostly due to reduced reporting in times before GLP. Rats were exposed for 3 min and 1 h, respectively, to a vapour saturated atmosphere. Concentration was stated in the raw data to be 1.385 mg/L in the case of the 3 min exposure and 1.019 mg/L in case of the 1 h exposure. A measured concentration of 40 ppm of phosgen above the test substance in the 3 min trial indicates a partial hydrolisation of the test substance.
12/12 animals died within 2 h after 3 min exposure to 1.385 mg/L; 3/10 animals died within 6 d after 1 h exposure to 1.019 mg/L.Animals of the 3 min exposure showed vigorous attempts to escape, extremely severe irritation to the mucosa and gasping; animals of the 1 h exposure showed restlessness, irritation to the mucosa and dyspnea.
Necropsy findings were congestion and edema of the lungs in the 3 min treatment and acute pulmonary emphysema in the 1 h treatment, respectively.
Inhalation of 1.385 mg/L propyl chloroformate for 3 min or 1.019 mg/L for 1 h may cause death. According to CLP No. 1272/2008 Part 3.1.2, for the conversion from 1 h to 4 h exposure, the data are divided by factor 2.
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