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EC number: 203-583-1 | CAS number: 108-44-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: inherent biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Principles of method if other than guideline:
- - batch system (comparable to Zahn-Wellens Test OECD TG 302B)
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, adapted
- Details on inoculum:
- - activated sludge was adapted to p-toluidine in laboratory prior to testing
- TS concentration was gradually increased up to 200 mg/l COD during the adaptation period of 20 days
- inoculum concentration applied was 100 mg/l dry matter - Duration of test (contact time):
- 120 h
- Initial conc.:
- 200 mg/L
- Based on:
- COD
- Parameter followed for biodegradation estimation:
- other: COD
- Parameter:
- other: removed COD
- Value:
- 97.7
- Sampling time:
- 5 d
- Details on results:
- removed COD after 5 days: 97.7%
rate of biodegradation after 5 days: 30.0 mg COD g/h
In a Zahn-Wellens test conducted with adapted inocolum after 5 days 97.7 % of the initial concentration (200 mg/l COD) as the sole source of carbon had been removed (Pitter, 1976). - Validity criteria fulfilled:
- not specified
- Remarks:
- Since the test is poorly reported the validity criteria cannot be assessed sufficiently. Nevertheless the test is considered as valid based on the data given.
- Interpretation of results:
- inherently biodegradable
- Conclusions:
- The substance is inheretly biodegradable.
- Executive summary:
With a test design comparable to Zahn-Wellens Test OECD TG 302B the inherent biodegradability was determined. The degradation was 97.7 % after 5 days related to COD. Therefore the substance is considered as inherently biodegradable.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test)
- Principles of method if other than guideline:
- Directive 84/449/EEC, C.3; ISO 7824 (1984) (precursor)
- GLP compliance:
- not specified
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: effluent of predominantly domestic STP
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 20 mg/L
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- -replicates per concentration: 2
- Reference substance:
- aniline
- Reference substance:
- other: hydroquinone
- Parameter:
- % degradation (DOC removal)
- Value:
- 64 - 84
- Sampling time:
- 28 d
- Details on results:
- degradation of m-toluidine (first run)
7 d: - 24 %
14 d: 91 %
21 d: 98 %
28 d: 84 %
degradation of m-toluidine (second run)
7 d: - 24 %
14 d: 83 %
21 d: 91 %
28 d: 64 %
negative values mean an increase of the DOC in the test system compared to the control, no explanation is given for these findings - Results with reference substance:
- - degradation of aniline fulfilled the pass level as 86 +/- 10 % (mean value) were degraded after 14 d
- degradation of hydroquinone showed a greater variability, but observed degradation after 14 d reached the pass level - Validity criteria fulfilled:
- yes
- Remarks:
- The pass level was reached within the 10 day window. The reference substance aniline fulfilled the pass level as 86 +/- 10 % (mean value) were degraded after 14 d.
- Interpretation of results:
- readily biodegradable
- Conclusions:
- With a degradation of 64 % and 84 % after 28 d the substance is considered as readily biodegradable
- Executive summary:
Testing m-toluidine towards ready biodegradability in a modified OECD screening test, 64 % to 84 % of the test item were degraded after 28 d, respectively (Trenel, 1982). Furthermore, the pass level is reached within the 10 day window. Thus, the substance can be scored as readily biodegradable.
Referenceopen allclose all
- The report includes results of a multitude of comopounds, whereas only the percentage degradation was reported. - as only these results were provided, where control samples fulfilled the validity criteria (stated by the authors), results are assumed to reliable - there is no explanation for the decreasing degradation observed after day 21, nevertheless observed degradation at day 28 exceeds the pass level of 70 % degradation - 10 d window: no specific information is presented, but as no degradation was observed on day 7 and 91 % and 83 %, respectively were degraded at day 14, the fullfilment of the 10 d window can be assumed
Description of key information
With a degradation of 64 % to 84 % after 28 d the substance is considered as readily
biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
Testing the substance towards ready biodegradability in a modified OECD screening test, 64 % to 84 % of the test item were degraded after 28 d, respectively. Furthermore, the pass level is reached within the 10 day window. Thus, the substance is considered as readily biodegradable.
With a guideline corresponding to the OECD guideline 301C no degradation was observed within 4 weeks. Though there is evidence that the test item inhibits the inoculum when tested at higher concentrations. As tests were performed testing 100 mg/L, and there is no information with respect to the performance of toxicity controls, no conclusion can be drawn whether the test item is really not biodegradable.
In an inherent biodegradation test the degradation was 97.7 % after 5 days indicating that the substance is inherently biodegradable. The test was performed with a test design comparable to Zahn-Wellens Test OECD TG 302B.
Biodegradation of chemicals (including m-toluidine) was tested under anaerobic conditions in aquifer slurries from a sulfate reducing and a methanogenic site. Degradation of m-toluidine could be detected after eight months, within 10 months 73 % of the test item were biodegraded in the sulfate reducing aquifer slurries, but no degradation could be detected in the methanogenic aquifer slurries.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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