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EC number: 606-278-5 | CAS number: 19257-34-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
LD50 oral (rat): > 2000 mg/kg bw [Kurth and Wick, 2000]
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Feb 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- 17 December 2001
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Tierzucht Schönwalde GmbH, Germany
- Weight at study initiation: males : 110-118 g; females : 101-107 g
- Fasting period before study: 18 - 18.5 hours
- Housing: individually, cage conditions: conventional
- Diet (e.g. ad libitum): pell. Altromin ®R ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21-22
- Humidity (%): 42-56
- Photoperiod (hrs dark / hrs light): 12/12
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0.9 % NaCl + 0.085 % Myrj 53 in bidist. water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 200 mg/mL
- Amount of vehicle (if gavage): 10mL/kg
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg
CLASS METHOD
- Rationale for the selection of the starting dose: Limit test - Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical observations: All animals were checked three times on administration day and once daily on the following days; body weight: Body weight was determined at the start (day 1), on day 7 and at the end (day 14) of the study.
- Necropsy of survivors performed: yes
- Clinical signs including body weight: All alterations of the baseline condition of the animals were recorded. - Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Not observed
- Clinical signs:
- other: Only observed in one animal one hour after dosing , all other animals showed no clinical signs.
- Gross pathology:
- No findings
- Conclusions:
- A single oral administration of the test substance by gavage to male and female rats at the limit-dose 2000 mg/kg was tolerated without mortalities, effects on body weight gain and gross pathological findings. At 2000 mg/kg slight apathy and reddened rhinorrhea were observed in one male animal only one hour after administration. According to OECD TG 423 the oral LD50 of the test item is therefore > 2000 mg/kg body weight
- Executive summary:
In an acute oral toxicity study according to OECD TG 423 (adopted 17 December 2001), groups of fasted, Wistar rats, female and male weighing, (3/sex) were given a single oral dose of Dimethoxyketal in 0.9 % NaCl + 0.085 % Myrj 53 in bidist. water at a dose of 2000 mg/kg bw and observed for 14 days.
Oral LD50 Combined > 2000 mg/kg bwLimit test
No mortality occurred during the test
After single oral application of 2000 mg/kg one male animal showed slight apathy and reddened rhinorrhea only one hour after administration. All other animals were without clinical findings over the whole observation period. There were no necropsy findings or changes in body weight.The test item is of low Toxicity based on the LD50 in male and female Wistar rats.
Reference
No animal died in the course of the study. After single oral application of 2000 mg/kg one male animal showed slight apathy and reddened rhinorrhea only one hour after administration. All other animals were without clinical findings over the whole observation period. The body weight gain on days 7 and 14 was within the normal range for rats of this age and strain, which are routinely used in the laboratory. Autopsy revealed no compound-related findings.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In an acute oral toxicity study according to OECD TG 423 (adopted 17 December 2001), groups of fasted, Wistar rats, female and male weighing, (3/sex) were given a single oral dose of Dimethoxyketal in 0.9 % NaCl + 0.085 % Myrj 53 in bidist. water at a dose of 2000 mg/kg bw and observed for 14 days.
Oral LD50 Combined => 2000 mg/kg bw
Limit test
No mortality occurred during the test
After single oral application of 2000 mg/kg one male animal showed slight apathy and reddened rhinorrhea only one hour after administration. All other animals were without clinical findings over the whole observation period. There were no necropsy findings or changes in body weight.
The test item is of low Toxicity based on the LD50 in male and female Wistar rats.
Justification for classification or non-classification
Based on the study results a classification according to Regulation (EC) No. 1272/2008 (CLP) is not required.
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