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EC number: 205-851-3 | CAS number: 156-38-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study is peformed according to OECD testing guideline and GLP, and the report is well described. The presence of substance was measured during the assay.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- p-hydroxyphenylacetic acid
- EC Number:
- 205-851-3
- EC Name:
- p-hydroxyphenylacetic acid
- Cas Number:
- 156-38-7
- Molecular formula:
- C8H8O3
- IUPAC Name:
- p-hydroxyphenylacetic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): p-hydroxyphenylacetic acid
- Physical state: white powder
- Storage condition of test material: in a fume cupboard at 20°C in the dark
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 500 mg/L
- Sampling method: water samples were taken from the middle of the test chamber at study start, and after 48 and 96 hours.
- Sample storage conditions before analysis: no data
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: water for dilution was added to the substance, the mixture homogenised using an Ultra-Turrax and ultrasonic batch and poured into the chamber under stirring with a glass rod.
- Evidence of undissolved material (e.g. precipitate, surface film, etc): none
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebra fish
- Strain: Hamilton-Buchanan
- Source: West Aquarium(3422 Bad Lauterberg, FRG)
- Length at study initiation: 2.4 to 3.2 cm (mean: 2.9 cm ± 0.23 cm)
- Method of breeding: -
- Feeding during test: no
ACCLIMATION
- Acclimation period: at least 14 days before the start of the study
- Acclimation conditions (same as test or not): yes
- Type and amount of food: Tetra Min, Tetra Werke, Melle, twice daily ad libitum
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- none
Test conditions
- Test temperature:
- 22.3 to 22.6°C
- pH:
- 7.2 ot 8.2
- Dissolved oxygen:
- 6.9 to 8.7 mg/L
- Nominal and measured concentrations:
- Nominal concentrations: 0 and 500 mg/L
Measured concentrations: 499 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: 10-L test chambers, made out of glass (length 30cm, width 22cm, height 24cm)
- Type (delete if not applicable): no data
- Aeration: no
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: reconstituted water according to ISO/DIS 7346/1
OTHER TEST CONDITIONS
- Adjustment of pH: yes (adjusted to the pH-value of the dilution water by adding 1.8 mL of NaOH (10 mol/L)
- Photoperiod: 6:00 to 18:00 hrs
- Light intensity: approx. 700 lux
EFFECT PARAMETERS MEASURED:
lethality and visible changes in appearance and behaviour were recorded after 2, 4, 24, 48, 72 and 96 hours.
TEST CONCENTRATIONS
- Spacing factor for test concentrations: -
- Justification for using less concentrations than requested by guideline: limit test at 500 mg/L - Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 500 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Appearance and behavioural abnormalities: no changes observed.
- Mortality of control: 0/10
- Other adverse effects control: no changes in appearance and behaviour
No lethality was observed in the 500 mg/L group. - Reported statistics and error estimates:
- not applicable
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 96-h LC50 of p-hydroxyphenylacetic acid is above 500 mg/L.
- Executive summary:
The lethal effect of p-hydroxyphenylacetic acid was evaluated in zebra fish (Brachydanio rerio) over a total of 96 hours in a static test according to OECD testing guideline n° 203. No lethality occured at 500 mg/L (mean measured concentration: 499 mg/L).
The LC50 after 96 hours is therefore above 500 mg/L.
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