Registration Dossier
Registration Dossier
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EC number: 213-138-3 | CAS number: 926-57-8
Specific investigations: other studies
Administrative data
- Endpoint:
- nephrotoxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: MIGRATED DATASET. Original reference not translated, only short abstract available.
Data source
Reference
- Reference Type:
- publication
- Title:
- Gig. Tr. Prof. Zabol., (3):44-45
- Author:
- Petrosyan FR and Gizhlaryan MS
- Year:
- 1 985
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Enteric administration of 1,3-dichlorobut-2-ene to rats.
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- 1,3-dichlorobut-2-ene
- EC Number:
- 213-138-3
- EC Name:
- 1,3-dichlorobut-2-ene
- Cas Number:
- 926-57-8
- Molecular formula:
- C4H6Cl2
- IUPAC Name:
- 1,3-dichlorobut-2-ene
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- other: enteric
- Vehicle:
- water
- Remarks:
- 2.5% of body weight
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.25 and 0.75 the LD50 of 1,3-dichlorobut-2-ene
Basis:
Results and discussion
- Details on results:
- After 72 hours, rats exposed to enteric administration of 0.25 and 0.75 the LD50 of 1,3-dichlorobut-2-ene and loading with water (2.5% of body weight) showed above normal diuresis. The biochemical data as well as histopathological observations indicated renal tubular damage. The necrotic nephrosis is apparently due to the inhibition of renal tubular SH-group containing enzymes.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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