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EC number: 282-817-4 | CAS number: 84434-18-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, to GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- yes
- Remarks:
- modified by use of sealed vessels for assessment of volatile substances
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- N,2-dimethyl-N-phenylbutyramide
- EC Number:
- 282-817-4
- EC Name:
- N,2-dimethyl-N-phenylbutyramide
- Cas Number:
- 84434-18-4
- Molecular formula:
- C12H17NO
- IUPAC Name:
- N,2-dimethyl-N-phenylbutanamide
- Test material form:
- other: solid
- Details on test material:
- Name: Gardamide
Manufacturer's Code: 638014
Sample Description: White somewhat sharp smelling solid
Purity: Non-GLP 99.0%
Molecluar weight: 191.0 g/mol
% Carbon: calculated 75.4%
Hazards: Not known. Avoid contact with skin or eyes
Storage: Store at room temperature in the dark
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- Secondary effluent from an unacclimatised activated sludge plant at URL North.
- Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 10 mg/L
- Based on:
- test mat.
- Details on study design:
- The test used was the sealed vessel test which is suitable for determining the ready biodegradability and ultimate biodegradability of organic substances. The test is conducted in 160 mL vessels (hypovials) containing 100 mL mineral salts medium innoculated with secondary effluent and the respective test or reference substance. Mulitple vessels are prepared per substance sealed with a butyl rubber septum and an aluminium crimp seal. The headspace in each vessel has a volume of 60 mL and, when filled with air, contains approximately 6 times the mass of oxygen required for the complete oxidation of the substance.
The sealed vessels are incubated at 20 °C on a rotary shaker. At intervals during the 28 day test period a vessel is removed and the concentration of carbon dioxide in the headspace gas is determined. The seal is then broken and the concentration of the inorganic carbon in the test medium is also determined. The total inorganic carbon in the vessel is calculated and corrected by subtracting the total inorganic carbon produced in a control. The control vessels are identical to the test vessels except for the omission of the test substance, the extent of mineralisation can be determined.
Reference substance
- Reference substance:
- other: benzyl alcohol
Results and discussion
% Degradationopen allclose all
- Parameter:
- % degradation (inorg. C analysis)
- Value:
- 2
- Sampling time:
- 7 d
- Parameter:
- % degradation (inorg. C analysis)
- Value:
- 2.6
- Sampling time:
- 11 d
- Parameter:
- % degradation (inorg. C analysis)
- Value:
- 4.6
- Sampling time:
- 17 d
- Parameter:
- % degradation (inorg. C analysis)
- Value:
- 0
- Sampling time:
- 24 d
- Key result
- Parameter:
- % degradation (inorg. C analysis)
- Value:
- 0.7
- Sampling time:
- 28 d
BOD5 / COD results
- Results with reference substance:
- Benzyl alcohol was chosen as a reference substance because it has previously been shown to be readily biodegradable in the Sealed Vessel Test System. Benzyl alcohol achieved 96.3% biodegradation after 28 days and the 60% 'pass' level was reached within 10 days of exceeding the 10% level. Consequently benzyl alcohol can be classified as readily biodegradable thereby confirming the suitability of the inoculum and the culture condidtions of this study.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- In a guideline study, to GLP, Gardamide at 10 mg/L was not readily biodegradable in activated sludge (0.7% biodegradation at day 28).
- Executive summary:
Gardamide was evaluated for ready biodegradability in a sealed CO2 study (modified OECD 301 B) and to GLP. Gardamide failed the test and therefore cannot be classed as being readily biodegradable.
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