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Diss Factsheets
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EC number: 208-792-1 | CAS number: 541-73-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- 1,3-dichlorobenzene
- EC Number:
- 208-792-1
- EC Name:
- 1,3-dichlorobenzene
- Cas Number:
- 541-73-1
- Molecular formula:
- C6H4Cl2
- IUPAC Name:
- 1,3-dichlorobenzene
- Test material form:
- other: colorless liquid
- Details on test material:
- purity: 85.1%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Hoe: WISKf (SPF71)
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 5 m+ 5 f rats: 14.8 mg m-dichlorobenze/l air
5 m+ 5 f rats: 17.63 mg m-dichlorobenze/l air - No. of animals per sex per dose:
- 5 m+ 5 f rats: 14.8 mg m-dichlorobenze/l air
5 m+ 5 f rats: 17.63 mg m-dichlorobenze/l air - Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 17.6 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
Any other information on results incl. tables
After an expostion to 17.6 mg m-dichlorobenzene no of the animals died. The test atmosphere consited maily as vapor.
Based on this result, the LC50(4h) was > 17.6 mg dichlorobenzene/l.
Of the animals exposed to 14.8 mg m-dichlorobenene 2 male and 3 female rats died. The test atmosphere had a higher content of aerosol compared with the test group which received 17.6 mg m-dichlorobenzene/l air.
The animals exposed to 17.6 mg m-dichlorobenzene/l air showed unregular breathing, uncoordinated gait, ataxia, prone position, rough fur, drowsiness, tremor, constricted palpebral fissures, reduced startled reflexes, increased salivation and foamy nose effluent.
Animals which received furthermore reduced breathing rate, staggared gait, reducted activity, narcosis, coma, no startled reflexes, bloody nose and eye lids, closed palpebral fissures, reduced body temperature, convulsions, cyanosis bad nutrition state and sneezing.
The section of animals which died intercurrent had darkred spots on the lungs, darkened liver and blood engorgement in the lungs. The animals which were killed after the post-observation period revealed no findings.
Applicant's summary and conclusion
- Interpretation of results:
- other:
- Remarks:
- LC50(4h) > 17.6 mg m-dichlorobenzene (vapour)/l air.
- Executive summary:
Five male and five female Wistar rats were exposed nose-only for 4 hours to concentrations of 14.8 or 17.63 mg dichlorobenzene/liter air. Animals were observed for mortality, body weight and clinical signs during a post-observation period of 14 days. A necropsy was performed on the animals at the end of the post-observation period.
The LC50(4h) was > 17.6 mg m-dichlorobenzene (vapour)/l air.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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