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Diss Factsheets
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EC number: 670-981-3 | CAS number: 80806-68-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Remarks:
- The study was conducted according to guideline in effect at time of study conduct.
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2400 (Acute Eye Irritation)
- Deviations:
- no
- Remarks:
- The study was conducted according to guideline in effect at time of study conduct.
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- no
- Remarks:
- The study was conducted according to guideline in effect at time of study conduct.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctan-1-ol
- EC Number:
- 211-477-1
- EC Name:
- 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctan-1-ol
- Cas Number:
- 647-42-7
- Molecular formula:
- C8H5F13O
- IUPAC Name:
- 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctan-1-ol
- Details on test material:
- -Purity: 99.7%
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Age at study initiation: young adult
- Weight at study initiation: 3250-3615 g
- Housing: Singly in stainless steel, wire-mesh cages suspended above cage boards
- Diet (e.g. ad libitum): 125 g rabbit diet daily
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 16-22°C
- Humidity (%): 30-70%
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light):artificially illuminated (fluorescent light) approximately 12 hour dark/12 hour light
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the left eye of each rabbit served as a control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL - Duration of treatment / exposure:
- single exposure
- Observation period (in vivo):
- 1, 24, 48, 72 hours
- Number of animals or in vitro replicates:
- 3 males
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): eyes remained unwashed
SCORING SYSTEM: Draize scale for scoring ocular lesions. Any other adverse ocular reactions were also noted.
TOOL USED TO ASSESS SCORE: Approximately 1, 24, 48, and 72 hours after administration, the rabbits were examined for evidence of eye irritation. At each observation period, eyes were examined using illumination and magnification and scored for ocular reactions. Fluorescein stain examinations were conducted at the 24-hour and each subsequent evaluation.
Results and discussion
In vivo
- Irritant / corrosive response data:
- Iritis (score of 1) was observed in the treated eye of 1 rabbit, conjunctival redness (score of 1, 2, or 3) was observed in the treated eyes of 3 rabbits, conjunctival chemosis (score of 1) was observed in the treated eye of 1 rabbit, and discharge (score of 1) was observed in the treated eye of 1 rabbit. Fluorescein stain examinations were negative for corneal injury in the treated eyes of the rabbits throughout the study. The treated eyes of the rabbits were normal by 24 or 48 hours after instillation of the test substance. See Table 1 for Individual Animal Data.
Any other information on results incl. tables
Table 1: Individual Animal Ocular Effects |
||||||||
Rabbit Number |
Cornea |
Iritis |
Conjunctiva |
Fluorescein Stain |
||||
Opacity |
Area |
Redness |
Chemosis |
Discharge |
||||
1 Hour |
184 |
0 |
0 |
0 |
2 |
1 |
0 |
NA |
203 |
0 |
0 |
0 |
2 |
0 |
1 |
NA |
|
204 |
0 |
0 |
1 |
3 |
0 |
0 |
NA |
|
24 Hours |
184 |
0 |
0 |
0 |
0 |
0 |
0 |
Neg |
203 |
0 |
0 |
0 |
1 |
0 |
0 |
Neg |
|
204 |
0 |
0 |
0 |
1 |
0 |
0 |
Neg |
|
48 Hours |
184 |
0 |
0 |
0 |
0 |
0 |
0 |
Neg |
203 |
0 |
0 |
0 |
0 |
0 |
0 |
Neg |
|
204 |
0 |
0 |
0 |
0 |
0 |
0 |
Neg |
|
72 Hours |
184 |
0 |
0 |
0 |
0 |
0 |
0 |
Neg |
203 |
0 |
0 |
0 |
0 |
0 |
0 |
Neg |
|
204 |
0 |
0 |
0 |
0 |
0 |
0 |
Neg |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance is slightly irritating but does not met the CLP criteria
The study and the conclusions which are drawn from it fulfil the quality criteria (validity, reliability, repeatability). - Executive summary:
The test substance was evaluated for acute eye irritation potential in 3 young adult New Zealand white rabbits. An aliquot of 0.1 mL of the test substance was administered to 1 eye of each animal. The eyes remained unwashed following treatment. The untreated eye served as a control. The conjunctiva, iris, and cornea of each treated eye were evaluated and scored according to a numerical scale approximately 1, 24, 48, and 72 hours following administration. Under the conditions of this study, the test substance produced iritis, conjunctival redness, conjunctival chemosis, and discharge when instilled into the rabbit eye. All ocular irritation reversed by 48 hours.
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