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EC number: 500-045-0 | CAS number: 26027-38-3 1 - 2.5 moles ethoxylated
Endpoint summary
Administrative data
Description of key information
Biodegradation in water
Biodegradation study was conducted for 21 days for evaluating the percentage biodegradability of test substance 4-Nonylphenol, ethoxylated (CAS no. 26027 -38 -3) (J-CHECK, 2017). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l. The percentage degradation of test substance was determined to be 0% degradation by BOD, O2 consumption, test mat. analysis and UV-Vis and 14.3% degradation by TOC removal parameter in 21 days. Thus, based on percentage degradation, 4-Nonylphenol, ethoxylated was considered to be not readily biodegradable in nature.
Biodegradation in water and sediment
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 4-Nonylphenol, ethoxylated (CAS No. 26027 -38 -3). If released in to the environment, 11.6% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 4-Nonylphenol, ethoxylated in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of 4-Nonylphenol, ethoxylated in sediment is estimated to be 337.5 days (8100 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.864%), indicates that 4-Nonylphenol, ethoxylated is not persistent in sediment.
Biodegradation in soil
The half-life period of 4-Nonylphenol, ethoxylated (CAS No. 26027 -38 -3) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 87.6% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 4-Nonylphenol, ethoxylated in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of 4-Nonylphenol, ethoxylated, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
Additional information
Biodegradation in water
Various experimental and predicted data for the target compound 4-Nonylphenol, ethoxylated (CAS No. 26027-38-3) and supporting studies for its read across were reviewed for the biodegradation end point which are summarized as below:
In an experimental key study from authoritative database (J-CHECK, 2017), biodegradation study was conducted for 21 days for evaluating the percentage biodegradability of test substance 4-Nonylphenol, ethoxylated (CAS no. 26027 -38 -3). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l. The percentage degradation of test substance was determined to be 0% degradation by BOD, O2 consumption, test mat. analysis and UV-Vis and 14.3% degradation by TOC removal parameter in 21 days. Thus, based on percentage degradation, 4-Nonylphenol, ethoxylated was considered to be not readily biodegradable in nature.
Another biodegradation study was conducted for 21 days for evaluating the percentage biodegradability of test substance 4-Nonylphenol, ethoxylated (CAS no. 26027 -38 -3) (J-CHECK, 2017). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l. The percentage degradation of test substance was determined to be 0% degradation by BOD, O2 consumption, test mat. analysis and UV-Vis and 10.3% degradation by TOC removal parameter in 21 days. Thus, based on percentage degradation, 4 -Nonylphenol, ethoxylated was considered to be not readily biodegradable in nature.
In a prediction using the Estimation Programs Interface Suite (EPI suite, 2017), the biodegradation potential of the test compound 4-Nonylphenol, ethoxylated (CAS no. 26027 -38 -3) in the presence of mixed populations of environmental microorganisms was estimated. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 4-Nonylphenol, ethoxylated is expected to be not readily biodegradable.
For the read across chemical Polyoxyethylene( 15)tallow amine (CAS no. 61791-26-2) from peer reviewed journal (C. G. van Ginkel et. al; 1993), the biodegradation study was carried out using prolonged closed bottle test for testing percent biodegradation of read across chemical Polyoxyethylene( 15)tallow amine according to OECD guideline 301D at temperature 20oC. Secondary activated sludge was used as inoculums. The percent biodegradation obtained for chemical Amines, ethoxylated(1 - 4.5 moles ethoxylated) of CAS no. 61791-26-2 was 28 % in 28 days and 67 % in 214 days According to these percentage value and duration it is concluded that the chemical Amines, ethoxylated (1 - 4.5 moles ethoxylated) of CAS no. 61791-26-2 is not readily biodegradable..
On the basis of above results for target chemical 4 -Nonylphenol, ethoxylated (from authoritative database J-CHECK and EPI suite, 2017) and for its read across substance (from peer reviewed journal), it can be concluded that the test substance 4 -Nonylphenol, ethoxylated can be expected to be not readily biodegradable in nature.
Biodegradation in water and sediment
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 4-Nonylphenol, ethoxylated (CAS No. 26027 -38 -3). If released in to the environment, 11.6% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 4-Nonylphenol, ethoxylated in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of 4-Nonylphenol, ethoxylated in sediment is estimated to be 337.5 days (8100 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.864%), indicates that 4-Nonylphenol, ethoxylated is not persistent in sediment.
Biodegradation in soil
The half-life period of 4-Nonylphenol, ethoxylated (CAS No. 26027 -38 -3) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 87.6% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 4-Nonylphenol, ethoxylated in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of 4-Nonylphenol, ethoxylated, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
On the basis of available information, the test substance 4 -Nonylphenol, ethoxylated can be considered to be not readily biodegradable in nature.
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