Registration Dossier
Registration Dossier
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EC number: 231-992-5 | CAS number: 7783-35-9
Toxicity to reproduction
Administrative data
- Endpoint:
- fertility, other
- Remarks:
- based on test type (migrated information)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of PCBs, DDT, and mercury compounds in chickens and Japanese quail
- Author:
- Scott ML
- Year:
- 1 977
- Bibliographic source:
- Fed Proc. 1977 May;36(6):1888-93.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as per mentioned below
- Principles of method if other than guideline:
- The reprotoxicity was performed on white leghorn chickens by mercury sulphate(7783-35-9)
- GLP compliance:
- no
Test material
- Reference substance name:
- Mercury sulphate
- EC Number:
- 231-992-5
- EC Name:
- Mercury sulphate
- Cas Number:
- 7783-35-9
- Molecular formula:
- H2O4S.Hg
- IUPAC Name:
- mercury sulfate
- Details on test material:
- - Name of test material: Mercury sulphate
- Molecular formula: H2O4S.Hg
- Molecular weight : 298.67 g/mol
- Smiles notation: [O-]S(=O)(=O)[O-].[Hg+2]
- InChl : InChI=1S/Hg.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)/q+2;/p-2
- Substance type: Solid
- Physical state: Inorganic
- Impurities (identity and concentrations): No data
Constituent 1
Test animals
- Species:
- other: Chickens
- Strain:
- other: Breed: white leghorn
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: feed
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- other: Diet
- Details on exposure:
- No data available
- Details on mating procedure:
- No data available
- Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- No data available
- Duration of treatment / exposure:
- No data available
- Frequency of treatment:
- Daily
- Details on study schedule:
- No data available
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100 and 200 ppm (100 and 200 mg/kg)(Convert by general google converter)
Basis:
nominal in diet
- No. of animals per sex per dose:
- No data available
- Details on study design:
- No data available
- Positive control:
- No data available
Examinations
- Parental animals: Observations and examinations:
- No data available
- Oestrous cyclicity (parental animals):
- No data available
- Sperm parameters (parental animals):
- No data available
- Litter observations:
- No data available
- Postmortem examinations (parental animals):
- No data available
- Postmortem examinations (offspring):
- No data available
- Statistics:
- No data available
- Reproductive indices:
- No data available
- Offspring viability indices:
- No data available
Results and discussion
Results: P0 (first parental generation)
General toxicity (P0)
- Clinical signs:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Other effects:
- not specified
Reproductive function / performance (P0)
- Reproductive function: oestrous cycle:
- not specified
- Reproductive function: sperm measures:
- not specified
- Reproductive performance:
- not specified
Effect levels (P0)
- Dose descriptor:
- LOEL
- Effect level:
- 200 mg/kg diet
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: egg production, hatchability, shell quality, morbidity and mortality
Results: F1 generation
General toxicity (F1)
- Clinical signs:
- not specified
- Mortality / viability:
- not specified
- Body weight and weight changes:
- not specified
- Sexual maturation:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Histopathological findings:
- not specified
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The endpoint for reprotoxicity to chicken by mercury sulphate(7783-35-9) was found to be LOEL at 200 mg/kg concentration.
- Executive summary:
The reprotoxicity was performed on white leghorn chickens by mercury sulphate(7783-35-9) .Chickens are given chemical at dietary level as 100 and 200 mg/kg and after treatment little effect was observed on egg production, hatchability, shell quality, morbidity and mortality.
Therefore, the endpoint for reprotoxicity to chicken by mercury sulphate(7783-35-9) was found to be LOEL at 200 mg/kg concentration.
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