Registration Dossier
Registration Dossier
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EC number: 203-254-2 | CAS number: 104-94-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Data from study report
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Reference Type:
- review article or handbook
- Title:
- RTECS Number : BZ5450000
- Author:
- RTECS handbook
- Year:
- 2 016
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances); BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 3,44,1948
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as per mentioned below
- Principles of method if other than guideline:
- Acute Dermal toxicity study was conducted on rats
- GLP compliance:
- no
- Test type:
- other: Not reported
Test material
- Reference substance name:
- p-anisidine
- EC Number:
- 203-254-2
- EC Name:
- p-anisidine
- Cas Number:
- 104-94-9
- Molecular formula:
- C7H9NO
- IUPAC Name:
- 4-methoxyaniline
- Details on test material:
- - Name of test material: 4-methoxyaniline
- Molecular formula: CH3OC6H4NH2
- Molecular weight: 123.15 g/mol
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- other: Dermal
- Vehicle:
- not specified
- Details on dermal exposure:
- no data
- Duration of exposure:
- Not reported
- Doses:
- Not reported
- No. of animals per sex per dose:
- Not reported
- Control animals:
- not specified
- Details on study design:
- Not reported
- Statistics:
- Not reported
Results and discussion
- Preliminary study:
- Not reported
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 200 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Not reported
- Clinical signs:
- Not reported
- Body weight:
- Not reported
- Gross pathology:
- Not reported
- Other findings:
- Not reported
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal LD50 in rats after dermal exposure to 4 methoxyaniline is 3200mg/kgw
- Executive summary:
Acute Dermal toxicity study was conducted on rats.
The rats were dermally dosed with the test chemical and effects were observed. The acute dermal LD50 in rats after oral exposure to 4 methoxyaniline in 3200mg/kgw
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