3-phenylpropionyl chloride

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from peer reviewed journal

Data source

Reference

Reference Type:

publication

Title:

A toxicological and dermatological assessment of aryl alkyl alcohol simple acid ester derivatives when used as fragrance ingredients

Author:

D. Belsito , D. Bickers , M. Bruze , P. Calow , M.L. Dagli , A.D. Fryer ,H. Greim , Y. Miyachi , J.H. Saurat , I.G. Sipes

Year:

2012

Bibliographic source:

Food and Chemical Toxicology, 50 (2012) S269–S313

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 405 (Acute Eye Irritation / Corrosion)

Principles of method if other than guideline:

An ocular irritation test was conducted for test chemical 2-phenylethyl 2-methylpropanoate (CAS no: 103-48-0) in four rabbits according to OECD test guideline 405.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2-phenylethyl 2-methylpropanoate

Cas Number:

103-48-0

Molecular formula:

C12H16O2

IUPAC Name:

2-phenylethyl 2-methylpropanoate

Test material form:

liquid

Details on test material:

- Name of test material (as cited in study report): Phenethyl isobutyrate- Molecular formula: C12H16O2- Molecular weight: 192.2564 g/mol- Substance type: organic - Physical state: Liquid- Smiles notation: c1(CCOC(C(C)C)=O)ccccc1- InChl: 1S/C12H16O2/c1-10(2)12(13)14-9-8-11-6-4-3-5-7-11/h3-7,10H,8-9H2,1-2H3

Specific details on test material used for the study:

- Name of test material (as cited in study report): Phenethyl isobutyrate- Molecular formula: C12H16O2- Molecular weight: 192.2564 g/mol- Substance type: organic - Physical state: Liquid- Smiles notation: c1(CCOC(C(C)C)=O)ccccc1- InChl: 1S/C12H16O2/c1-10(2)12(13)14-9-8-11-6-4-3-5-7-11/h3-7,10H,8-9H2,1-2H3

Test animals / tissue source

Species:

rabbit

Strain:

not specified

Details on test animals or tissues and environmental conditions:

no data

Test system

Vehicle:

unchanged (no vehicle)

Controls:

yes

Amount / concentration applied:

Amount: 0.1mLconcentration applied:100%

Duration of treatment / exposure:

48 hours

Observation period (in vivo):

48 hours

Duration of post- treatment incubation (in vitro):

no data

Number of animals or in vitro replicates:

4

Details on study design:

no data

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

48 h

Reversibility:

fully reversible

Remarks on result:

no indication of irritation

Irritant / corrosive response data:

Slight conjunctive irritation (4/4) was observed 1 h after application. All effects were reversible within 48 h.

Applicant's summary and conclusion

Interpretation of results:

other: Not irritating

Conclusions:

The test chemical 2-phenylethyl 2-methylpropanoate (CAS no: 103-48-0) was considered to be not irritating to the rabbits’ eye in an eye irritation test performed according to OECD test guideline 405.

Executive summary:

An ocular irritation test was conducted for test chemical 2-phenylethyl 2-methylpropanoate (CAS no: 103-48-0) in four rabbits in accordance with OECD test guideline 405.

 

The undiluted 2-phenylethyl 2-methylpropanoate was administrated into the eye of each rabbits and reactions were scored for 48 hours.

 

Slight conjunctive irritation (4/4) was observed 1 h after application. All effects were reversible within 48 h.

 

As all the observed effects were not persisted over a period of 48 hours, the chemical 2-phenylethyl 2-methylpropanoate was considered to be not irritating to the rabbits’ eye.