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EC number: 233-864-4 | CAS number: 10401-55-5
Water solubility
Administrative data
Link to relevant study record(s)
Description of key information
<0.7 mg/L at 24 °C, pH = 7, referring to the ester components
Key value for chemical safety assessment
Additional information
There is no test for the water solubility of hexadecyl (R)-12-hydroxyoleate (CAS 10401-55-5) available. The water solubility is therefore based on studies performed with analogue substances and QSAR calculations for the components present in hexadecyl (R)-12-hydroxyoleate as well as QSAR calculations for the analogue substances.
The analogue substances are myristyl myristate (CAS 3234-85-3, C14/C14) and reaction mass of octadecyl heptanoate and octadecyl octanoate (EC-List No. 915-334-0, C18/C7 and C18/C8). They are structurally similar and with a shorter chain length than the target substance seen as a kind “worst case” as the water solubility is a property decreasing with increasing overall chain length. For myristyl myristate a water solubility of <0.02 mg/L at 22 °C was measured with slow stirring method and analytic by GC-MS. For the reaction mass of octadecyl heptanoate and octadecyl octanoate
the water solubility was determined to be <0.7 mg/L at 24 °C, pH=7.1-7.9.Calculations for the three components of both analogue substances (C14/C14, C18/C7, C18/C8) reveal lower results:
C18/C7: 0.0002 mg/L, pH=7
C18/C8: 0.00003 mg/L, pH=7
C14/C14: 0.000005 mg/L, pH=7
So the calculated values for the components of hexadecyl (R)-12-hydroxyoleate (hexadecyl ricinoleate (A), hexadecyl oleate (B) and hexadecyl bisricinoleate (C)) will be also lower then test results. The calculated results are:
(A) 0.000003 mg/L, pH=7
(B) 0.0000003 mg/L, pH=7
(C) 0.0000000009 mg/L, pH=7
Taken the substance containing the most soluble component (C18/C7) in this weight of evidence approach (WS <0.7 mg/L) as basis, the water solubility of the target substance hexadecyl (R)-12-hydroxyoleate (CAS 10401-55-5) is concluded to be <0.7 mg/L at pH=7.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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