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Diss Factsheets
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EC number: 202-085-1 | CAS number: 91-63-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
In EFSA Journal (2008) 792,1-63 some generic considerations regarding the metabolism of methylquinoline are reported: methylquinoline are expected to be metabolised by hydroxylation of the ring structure in both rings, some diol metabolites may be formed through epoxide intermediates, hydroxylation of the alkyl groups is expected to be another main metabolic pathway and the quinolines may be oxidised at the heteroatom leading to N-oxide metabolites.
Some specific information regarding the metabolism of 2 -methylquinoline is summarised in NTP,2002.
In fact, as reported in Summary report of Toxicological Literature for Methylquinolines, NTP,2002 with reference to Saeki et al.,Biol. Pharm. Bull. 19(4):541-546, 1996, when tested in vitro, 2-methylquinoline was metabolized to 2-methylquinoline-5,6dihydro-5,6-diol.
Different pathway of metabolism for 2-methylquinoline are observed based on route of subministration. As reported in Summary report of Toxicological Literature for Methylquinolines, NTP,2002 with reference to Komiya, Nichidai Igaku Zasshi 24(7):649-663, 1965. Abstract from CAPLUS 1967:63977 when 2-methylquinoline was injected subcutaneously in rabbit 3-hydroxyquinaldine, 6-hydroxyquinaldine, quinaldic acid and several unknown compounds were excreted in the urine but when given orally 2-methylquinoline was excreted unchanged.
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