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Diss Factsheets
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EC number: 205-476-5 | CAS number: 141-27-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given: comparable to guideline method
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method: BASF-test according to internal SOP
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Citral
- EC Number:
- 226-394-6
- EC Name:
- Citral
- Cas Number:
- 5392-40-5
- IUPAC Name:
- 3,7-dimethylocta-2,6-dienal
- Reference substance name:
- (Z)-3,7-dimethylocta-2,6-dienal
- EC Number:
- 203-379-2
- EC Name:
- (Z)-3,7-dimethylocta-2,6-dienal
- Cas Number:
- 106-26-3
- Molecular formula:
- C10H16O
- IUPAC Name:
- 3,7-dimethylocta-2,6-dienal
- Details on test material:
- 3,7-Dimethyloctadien-2,6-al-1 (Citral)
Purity: >= 95 %
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gassner
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
0.5 % aqueous CMC preparation with 2-3 drops Cremophor EL as emulsifier
VOLUME APPLIED: 20 ml/kg (highest dose), 13.63 ml/kg (6810 mg/kg dose) and 10 ml/kg (three lowest doses) - Doses:
- 2150, 3160, 4640, 6810 and 10000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations (clinical signs): < 15, 15 and 30 min, 1, 2, 4 and 5 h, further on daily
- Frequency of weighing: at the beginning of the experiment, on day 3 and 7 and at the end of the experiment
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 6 800 mg/kg bw
- Mortality:
- see Table 1
- Clinical signs:
- other: 10000 mg/kg bw: the animals showed salivation, apathy, staggering, abdominal and lateral position, atony, narcotic state and no pain reflex before death. 6810 mg/kg bw: some animals showed apathy (1 h), staggering (1 h-5 h), salivation (15 min - 1 h), ruf
- Gross pathology:
- Dead animals: acute dilatation of the atriums; acute, congestive hyperemia; liver: peripheral lobule marking; intestine: atonic; thorax: sporadic hydrothorax;
Sacrificed animals: forestomach thickened, sporadic boutons, agglutinations with spleen and peritoneum
Any other information on results incl. tables
Pretest:
Mortality: 2/2 animals at 10,000 mg/kg bw, 1/2 animals at 4640 mg/kg bw, 0/2 animals at 1000, 215 or 46.4 mg/kg bw
Table 1: Mortality in main study
Dose (mg/kg bw) | No. of animals | Mortality within | ||||
1h | 24 h | 48 h | 7 d | 14 d | ||
10000 | 5M | 0/5 | 4/5 | 5/5 | 5/5 | 5/5 |
5F | 0/5 | 4/5 | 5/5 | 5/5 | 5/5 | |
6810 | 5M | 0/5 | 0/5 | 2/5 | 2/5 | 2/5 |
5F | 0/5 | 0/5 | 1/5 | 2/5 | 2/5 | |
4640 | 5M | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 |
5F | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | |
3160 | 5M | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 |
5F | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | |
2150 | 5M | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 |
5F | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 |
Table 2: Mean body weight (male/female in g)
Dose (mg/kg bw) | 0 d | 3d | 7d | 14d |
10000 | 220/160 | - | - | - |
6810 | 200/150 | 209/158 | 160/170 | 218/189 |
4640 | 200/160 | 210/168 | 209/173 | 224/187 |
3160 | 200/150 | 223/163 | 209/174 | 243/188 |
2150 | 170/150 | 205/170 | 227/145 | 211/188 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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