Registration Dossier
Registration Dossier
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EC number: 212-338-8 | CAS number: 791-28-6
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Abstract available only.
Data source
Reference
- Reference Type:
- publication
- Title:
- Initial submission: Letter from Rohm & Haas to USEPA: Toxicity studies of triphenylphosphine and triphenylphosphine oxide with attachments & cover letter dated 092292
- Author:
- Rohm & Haas Co
- Year:
- 1 992
- Bibliographic source:
- U.S.E.P.A., TSCATS OTS0570648, New Doc.I.D. 88-920008034
Materials and methods
- Principles of method if other than guideline:
- Method: other: no data
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Triphenylphosphine oxide
- EC Number:
- 212-338-8
- EC Name:
- Triphenylphosphine oxide
- Cas Number:
- 791-28-6
- Molecular formula:
- C18H15OP
- IUPAC Name:
- triphenylphosphine oxide
- Details on test material:
- Triphenylphosphine oxide
Purity: not reported
Constituent 1
Test animals
- Species:
- dog
- Strain:
- Beagle
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Duration of treatment / exposure:
- 4 weeks
- Frequency of treatment:
- 6 h/day, 5 days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
10.5 and 78.5 mg/m3
Basis:
- No. of animals per sex per dose:
- 2
- Control animals:
- other: yes, isopropanol
- Details on study design:
- Post-exposure period: 4 weeks
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 78.5 mg/m³ air
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: no effects observed
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
There were no signs of reaction to the treatment such as
neuromuscular incoordination or impairment during or after
the exposure.
The pathology report on tissue evaluation revealed no pattern of gross lesions or abnormalities.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
