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EC number: - | CAS number: 75045-07-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In 2 valid oral toxicity studies with 2-mercaptomethylbenzimidazole a LD50 = 340 mg/kg bw (rat, male) (Loeser) and a LD50 = 330 mg/kg bw (rat, male/female) (Saitoh) was found. In an acute oral toxicity study with the corresponding zinc salt (2-mercaptomethylbenzimidazole, zinc salt CAS no 61617-00-3) a LD50 = 390 mg/kg bw was determined.
Acute inhalative toxicity was tested with methyl-2-mercaptobenzimidazole, zinc salt in male and female Sprague-Dawley rats. Rats were exposed nose only for 4 hours at room temperature to a concentration of 0 and 2120 mg/m³. No mortality was observed.
A valid study for dermal toxicity determined a LD50 > 2000 mg/kg bw. At 2000 mg/kg bw none of 10 animals died.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well documented and scientifically acceptable
- Principles of method if other than guideline:
- Seven groups of 10 young adult male Wistar rats (160 -180 g) were dosed at 200, 300, 350, 380, 400, 450, or 500 mg/kg bw Vulkanox MB 2 (CAS 53988-10-6) in Lutrol. The animals were observed for mortality, body weights and clinical signs through day 14
- GLP compliance:
- no
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Doses:
- 200, 300, 350, 380, 400, 450, or 500 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 340 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- harmful
- Remarks:
- Migrated information
- Executive summary:
Seven groups of 10 young adult male Wistar rats (160 -180 g) were dosed at 1 200, 300, 350, 380, 400, 450, or 500 mg/kg bw Vulkanox MB 2 (CAS 53988-10-6) in Lutrol. The animals were observed for mortality, body weights and clinical signs through day 14.
Corresponding mortality was 0, 20, 70, 70, 80, 80 and 100% respectively. Sedation was the only clinical sign. Deaths occured on days 1 to 4. The acute oral LD50 for male rats is 340 mg/kg bw (95% confidence interval: 300 - 370 mg/kg bw).
Reference
Corresponding mortality was 0, 20, 70, 70, 80, 80 and 100% respectively. Sedation was the only clinical sign. Deaths occured on days 1 to 4. The acute oral LD50 for male rats is 340 mg/kg bw (95% confidence interval: 300 - 370 mg/kg bw).
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 340 mg/kg bw
- Quality of whole database:
- scientifically acceptable and sufficient documented
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary literature - U.S. Environmental Protection Agency, Hazard characterisation document sponsored Chemical: 2H-Benzimidazole-2-thione, 1,3-dihydro-, 4(or 5)-methyl-,zinc salt
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- Sprague-Dawley rats (5 per dose) were exposed nose-only to 0 or 2.12 mg/l of an aerosol of methyl-2-mercaptobenzimidazole, zinc salt for 4 hours
- GLP compliance:
- yes
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- 0 or 2.12 mg/l
- No. of animals per sex per dose:
- 10 male/female animals
- Control animals:
- yes
- Sex:
- male/female
- Dose descriptor:
- discriminating conc.
- Effect level:
- 2.12 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
Reference
There was no fatalities
Endpoint conclusion
- Dose descriptor:
- discriminating conc.
- Value:
- 2 120 mg/m³ air
- Quality of whole database:
- cited from secondary literature - no access, cited owing to all available data requirement
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary literature - U.S. Environmental Protection Agency, Hazard characterisation document sponsored Chemical: 2H-Benzimidazole-2-thione, 1,3-dihydro-, 4(or 5)-methyl-,zinc salt
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- Test material was moistened with arachis oil and applied to an area of shorn skin. All test animals received a single dermal exposure of 2,000 mg/kg b.w. The test material was held in place by surgical gauze and self-adhesive bandage. The semi-occlusive wrap was removed after 24 hours and the excess material was wiped from the test animal.
Animals were examined for mortality, systemic toxicity, signs of dermal irritation, weight gain and necropsy. - GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Type of coverage:
- semiocclusive
- Vehicle:
- arachis oil
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 10 male/female animals
- Control animals:
- not required
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
- Executive summary:
Test material was moistened with arachis oil and applied to an area of shorn skin. All test animals received a single dermal exposure of 2,000 mg/kg b.w. The test material was held in place by surgical gauze and self-adhesive bandage. The semi-occlusive wrap was removed after 24 hours and the excess material was wiped from the test animal.
LD50 > 2000 mg/kg bw. There were no deaths, no signs of systemic toxicity, no signs of dermal irritation and all animals showed expected weight gain. No abnormalities were noted at necropsy.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- cited from secondary literature - no access, cited owing to all available data requirement
Additional information
In 3 valid acute oral toxicity studies a LD50 > 330 mg/kg bw for male (and female) rats was found
In a study on rats with 2120 mg/m³ methyl 2-mercaptotobentimidazole, zinc salt (nose-only exposure) for 4 hours. No mortality was observed.
Ten male/female animals rats were exposed in an acute dermal toxicity study semicoocusively to methyl 2-mercaptotobentimidazole, zinc salt) for 24 hours. None of the rats died.
Justification for selection of acute toxicity – oral endpoint
key study used (LD50 of other studies were in the same range)
Justification for selection of acute toxicity – inhalation endpoint
only available data
Justification for selection of acute toxicity – dermal endpoint
only available data
Justification for classification or non-classification
The acute oral toxicity studies revealed a LD50 > 340 mg/kg bw. In the acute inhalation study and a LC50 > 2.12 mg/l was determined.
Therefore a classification as Xn; R20/22 (GHS: Acute Tox 4, H 332; Acute Tox 3, H 301) is justified. In an acute dermal toxicity study,
none of 10 animals died at 2000 mg/kg bw. Therefore a classification is not necessary.
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