Registration Dossier
Registration Dossier
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EC number: 610-527-3 | CAS number: 50407-76-6
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- GLP compliance:
- no
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- (8R,9S,10R,13S,14S,17R)-17-ethynyl-10,13-dimethyl-1,2,4,7,8,9,10,11,12,13,14,15,16,17,-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2´-[1,3]dioxolan]-17-ol
- EC Number:
- 610-527-3
- Cas Number:
- 50407-76-6
- Molecular formula:
- C23H32O3
- IUPAC Name:
- (8R,9S,10R,13S,14S,17R)-17-ethynyl-10,13-dimethyl-1,2,4,7,8,9,10,11,12,13,14,15,16,17,-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2´-[1,3]dioxolan]-17-ol
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 3.8
- Temp.:
- 25 °C
- pH:
- 5
- Details on results:
- Dead-time measured by Thiourea was 0.867 minutes.
In order to correlate the calculated capacity factor k of test item with its logPow, a calibration graph using six reference substances were used.
The value of partition coefficient of Ethisterone-ketal (CAS No. 50407-76-6) was determined by Microsoft Office Excel 2013. The following value was calculated: logPow= 3.8
Applicant's summary and conclusion
- Conclusions:
- The calculated mean logPow of Ethisterone-ketal: 3.8
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