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EC number: 237-525-1 | CAS number: 13826-35-2
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Metabolism in Rats of 3-Phenoxybenzyl Alcohol and 3-Phenoxybenzoic Acid Glucoside Conjugates Formed in Plants
- Author:
- Nobuyoshi Mikami, Jun Yoshimura, Hideo Kaneko, Hirohiko Yamada and Junshi Miyamoto
- Year:
- 1 985
- Bibliographic source:
- Pestic. Sci. 1985, 16, 33-45
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- The objective of the experiment was to study the metabolism in Rats of 3-Phenoxybenzyl Alcohol
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-phenoxybenzylic alcohol
- EC Number:
- 237-525-1
- EC Name:
- 3-phenoxybenzylic alcohol
- Cas Number:
- 13826-35-2
- Molecular formula:
- C13H12O2
- IUPAC Name:
- (3-phenoxyphenyl)methanol
- Details on test material:
- [14C]3-Phenoxybenzyl alcohol
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: 10% Tween 80 (1 ml)
- Details on exposure:
- The specific-pathogen free (SPF) and germ-free rats were each given a single oral dose of the 14C-preparations of 3-Phenoxybenzyl alcohol in 10% Tween 80 (1 ml) at a rate of 9 µmol kg-1. The SPF rats were individually housed in all-glass metabolism cages. The urine and faeces were collected separately for 1 day (germ-free rats), and for up to 7 days (SPF rats). At least four SPF and two germ-free rats were sacrificed at specified intervals for determination of 14C excretion and tissue residues, or for characterisation of the I4C metabolites.
- Duration and frequency of treatment / exposure:
- 7 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
9 µmol kg-1
- No. of animals per sex per dose / concentration:
- No data
- Control animals:
- not specified
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- 3-phenoxybenzyl alcohol was absorbed from the gastrointestinal tracts of the SPF rats.
- Type:
- distribution
- Results:
- Metabolites formed were distributed in the urine, bile and faeces.
- Type:
- metabolism
- Results:
- Following absorption, 3-phenoxybenzyl alcohol was rapidly oxidised to 3-phenoxybenzoic acid.
- Type:
- excretion
- Results:
- 99.4 (+ 0.6) of the administered radioactivity was excreted after 7 days of administration
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- 3-phenoxybenzoic acid and
3-(4-sulphonyloxyphenoxy)benzoic acid
Any other information on results incl. tables
Further details on metabolism
Following absorption, 3-phenoxybenzyl alcohol was rapidly oxidised to3-phenoxybenzoic acid. The acid was further metabolised by direct conjugation with glucuronide, and by hydroxylation primarily at the 4-position of the phenoxy ring, and subsequent conjugation with glucuronide and sulphate. The sulphate ester
3-(4-sulphonyloxyphenoxy)benzoic acid was rapidly eliminated in the urine, while the glucuronides were excreted in the bile and then cleaved in the gastrointestinal tract to afford 3-(4-hydroxyphenoxy)benzoic acid, which was reabsorbed and excreted in the urine as 3-(4-sulphonyloxyphenoxy)benzoic acid. These results were in good accord with those of the previous report. The sulphate conjugate 3-(4-sulphonyloxyphenoxy)benzoic acid was also excreted in the bile but to a lesser extent.However, it was fairly resistant to hydrolysis by the gut microflora, as compared with the glucose and glucuronide conjugates, and consequently corstituted a main metabolite of the intestinal contents and faeces
of the SPF rats. The sulphate codjugate 3-(4-sulphonyloxyphenoxy)benzoic acid was also a main faecal metabolite of the germ-free rats.
Meanwhile, the major metabolites were3-phenoxybenzoic acidand 3-(4-sulphonyloxyphenoxy)benzoic acid in the liver, and3-phenoxybenzoic acidin the blood.
3-Phenoxybenzyl alcohol (I) rapidly declined to the non-detectable level because of its rapid conversion to3-phenoxybenzoic acid.
Further details on excretion
The radioactivity excreted in the urine and faeces of SPF intact rats as % of the dose administered, following single oral administration of14C-3-phenoxybenzy1 alcohol is presented below:
0-1 day
In urine: 85.9 (+3.3)
In Feaces: 10.1(+3.3)
Total: 95.9 (+0.1)
0-7 days
Total: 99.4(+0.6)
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): low bioaccumulation potential based on study results
In an experiment to study the metabolism in Rats of 3-Phenoxybenzyl Alcohol, male SD rats were given a single oral dose of the 14C-preparations of 3-Phenoxybenzyl Alcohol in 10% Tween 80 (1 ml) at a rate of 9 µmol kg-1. The administered 3-Phenoxybenzyl Alcohol was absorbed in the GI tract and metabolized to 3-phenoxybenzoic acid and 3-(4-sulphonyloxyphenoxy) benzoic acid. At the end of 7 days, a total of 99.4 (+ 0.6) of the % of the dose administered was excreted out of the body of rats in urine and feaces.
Thus, it is concluded that the bioaccumulation potential of the chemical 3-Phenoxybenzyl Alcohol is expected to be low. - Executive summary:
In an experiment to study the metabolism in Rats of 3-Phenoxybenzyl Alcohol, male SD rats weregiven a single oral dose of the14C-preparationsof 3-Phenoxybenzyl Alcoholin 10% Tween 80 (1 ml) at a rate of 9 µmol kg-1. The administered3-Phenoxybenzyl Alcohol was absorbed in the GI tract and metabolized to3-phenoxybenzoic acidand 3-(4-sulphonyloxyphenoxy)benzoic acid. At the end of 7 days, a total of 99.4(+0.6)of the % of the dose administered was excreted out of the body of rats in urine and feaces.
Thus, it is concluded that the bioaccumulation potential of the chemical3-Phenoxybenzyl Alcoholis expected to be low.
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