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EC number: 269-941-4 | CAS number: 68391-30-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
An acute oral study was carried on Wistar rats to determine the acute oral toxicity of Basic Red 76. Groups of 3 male and 3 female rats received a single oral dose of 2000 mg/kg bw.
The LD50 was reported to be greater than 2000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- not specified
- Test type:
- other: No data
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data
- Route of administration:
- oral: gavage
- Vehicle:
- propylene glycol
- Details on oral exposure:
- VEHICLEConcentration in vehicle: Basic Red 76 in propylene glycolLot/batch no. (if required): 00506441 01 (of the target)MAXIMUM DOSE VOLUME APPLIED: 2000mg/kgbw
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- Groups of 3 male and 3 female rats
- Control animals:
- not specified
- Details on study design:
- Duration of observation period following administration: 14 days (or other?): 15 daysFrequency of observations and weighing: DailyNecropsy of survivors performed: yes/no: yes Other examinations performed: clinical signs, body weight, organ weights, histopathology, other: Animals were subjected to daily observations and weekly determination of body weight. Macroscopic examination was performed after terminal sacrifice (day 15).
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred
- Clinical signs:
- other: Hunched posture was noted in one female and 3 males on day 1. Red staining of the back and/or snout and/or head was noted in 1 female and 2 males between days 1 and 11.
- Gross pathology:
- No abnormalities were found at macroscopic post mortem examination of the animals.
- Other findings:
- Red and/or yellow faeces and/or yellow urine were seen among the animals on days 2 and/or 3.
- Interpretation of results:
- not classified
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- An acute oral study was carried on Wistar rats to determine the acute oral toxicity of Basic Red 76. Groups of 3 male and 3 female rats received a single oral dose of 2000 mg/kg bw.The LD50 was reported to be greater than 2000 mg/kg bw.
- Executive summary:
An acute oral study was carried on Wistar rats to determine the acute oral toxicity of Basic Red 76.
Basic Red 76 was administered by oral gavage to a group of three female Wistar rats and subsequently to a group of three male Wistar rats at 2000 mg/kg bw. Animals were subjected to daily observations and weekly determination of body weight. Macroscopic examination was performed after terminal sacrifice (day 15).
No mortality occurred. Hunched posture was noted in one female and 3 males on day 1. Red staining of the back and/or snout and/or head was noted in 1 female and 2 males between days 1 and 11. Red and/or yellow faeces and/or yellow urine were seen among the animals on days 2 and/or 3. The mean body weight gain over the study period was considered to be normal. No abnormalities were found at macroscopic post mortem examination of the animals.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- Data is of K4 level obtained from Scientific Committee on Consumer Safety SCCS - OPINION ON Basic Red 76
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute toxicity: Oral
In the Scientific Committee on Consumer Safety SCCS - OPINION ON Basic Red 76 (2011), An acute oral study was carried on Wistar rats to determine the acute oral toxicity of Basic Red 76. Groups of 3 male and 3 female rats received a single oral dose of 2000 mg/kg bw. The LD50 was reported to be greater than 2000 mg/kg bw.
In another study, an acute oral study was carried on CFY rats to determine the acute oral toxicity of Basic Red 76. Groups of 2 male and 2 female rats received oral dose of 0, 100, 1000, 4000, 8000, 16000 mg/kg in a volume of 1 to 40 ml/kg through gavage. The LD50 was reported to be greater than 16000 mg/kg bw.
Similarly, an acute oral study was carried on CF1 mice to determine the acute oral toxicity of Basic Red 76. Groups of 3 male mice received a single oral dose of Basic Red 76 at dose levels of 1000, 2510 and 5010 mg/kg bw, 10 male mice received the top dose of 10000 mg/kg bw. The LD50 was reported to be greater than 10000 mg/kg bw.
For a similar substance (CAS: 68391-32-2), acute oral toxicity studies are reported in SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS SCCP Opinion on Basic Brown 17 (2003)
CFY rats (male/female) were exposed orally to test chemical (8-((4-Amino-3-nitrophenyl)azo)-7-hydroxy-2-naphthyl)trimethylammonium chloride.
Based on the mortality of 2 male rats and 1 female rat from the highest dose group , the LD50 value was determined to be between 8000 and 16000 mg/kg bw, respectively.
Similarly, CF1 male mouse were exposed orally to test chemical(8-((4-Amino-3-nitrophenyl)azo)-7-hydroxy-2-naphthyl)trimethylammonium chloride.
The LD50value was determined to be greater than5000 mg/kg bw.
For a similar substance (CAS: 26381-41-9), acute oral toxicity studies are reported in Scientific Committee on Consumer Safety SCCS - OPINION ON Basic Brown 16 COLIPA n° C9 (2012)
CFY rats (male/female) were exposed orally to test chemical [8-[(p-aminophenyl)azo]-7-hydroxy-2-naphthyl]trimethylammonium chloride.
The LD50 was reported to be between 2000 and 4000 mg/kg bw.
Similarly, CF1 male mouse were exposed orally to test chemical [8-[(p-aminophenyl)azo]-7-hydroxy-2-naphthyl]trimethylammonium chloride.
LD50 was considered to be 7800 mg/kg bw when CF1male mice were treated with Basic Brown 16.
Overall reported acute toxicity studies of Basic Red 76 and its read-across substance, indicate that the substance is not likely to exhibit acute oral toxicity can be classified as 'non-hazardous' as per the CLP classification criteria.
Justification for selection of acute toxicity – oral endpoint
An acute oral study was carried on Wistar rats to determine the acute oral toxicity of Basic Red 76. Groups of 3 male and 3 female rats received a single oral dose of 2000 mg/kg bw.
The LD50 was reported to be greater than 2000 mg/kg bw.
Justification for classification or non-classification
On the basis of available data, the substance Basic red 76 is not likely to exhibit acute toxicity can be classified as 'non-hazardous' as per the CLP classification criteria.
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