Registration Dossier
Registration Dossier
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EC number: 224-909-9 | CAS number: 4548-53-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- REPORT BY THE SCIENTIFIC COMMITTEE ON COSMETOLOGY(Opinion expressed on 1. July 1986) CONCERNING CERTAIN COLOURING AGENTS
- Author:
- Directorate-General Environment, Consumer Protection and Nuclear Safety
- Year:
- 1 988
- Bibliographic source:
- Commission of the European Communities REPORTS of the Scientific Committee on Cosmetology (seventh series),1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Eye irritation test for chemical FD and C Red 4 was performed.
- GLP compliance:
- no
Test material
- Reference substance name:
- Disodium 3-[(2,4-dimethyl-5-sulphonatophenyl)azo]-4-hydroxynaphthalene-1-sulphonate
- EC Number:
- 224-909-9
- EC Name:
- Disodium 3-[(2,4-dimethyl-5-sulphonatophenyl)azo]-4-hydroxynaphthalene-1-sulphonate
- Cas Number:
- 4548-53-2
- Molecular formula:
- C18H16N2O7S2.2Na
- IUPAC Name:
- disodium 3-[(2,4-dimethyl-5-sulfonatophenyl)diazenyl]-4-hydroxynaphthalene-1-sulfonate
- Reference substance name:
- FD and C Red 4
- IUPAC Name:
- FD and C Red 4
- Details on test material:
- - Name of test material (as cited in study report):FD and C Red 4- Molecular formula (if other than submission substance):C18H14N207s2Na2- Molecular weight (if other than submission substance):480- Substance type:Organic- Physical state:Solid
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No data available
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- No data available
- Duration of treatment / exposure:
- No data available
- Observation period (in vivo):
- No data available
- Number of animals or in vitro replicates:
- No data available
- Details on study design:
- No data available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Reversibility:
- not specified
- Remarks on result:
- other: Not irritating
- Irritant / corrosive response data:
- Not irritating
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- Negative effects were known in eye irritation test of chemical FD and C red 4 exposed to the eye of rabbit.
- Executive summary:
Eye irritation test was conducted on rabbits exposed to chemical ED and C Red with 5% test chemical concentration.Negative effects were known in eye irritation test of chemical FD and C red 4 exposed to the eye of rabbit
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