Registration Dossier
Registration Dossier
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EC number: 908-381-3 | CAS number: -
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed to GLP and guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 10101-41-4
- EC Number:
- 600-148-1
- Cas Number:
- 10101-41-4
- IUPAC Name:
- 10101-41-4
- Reference substance name:
- calcium sulfate, dihydrate
- IUPAC Name:
- calcium sulfate, dihydrate
- Details on test material:
- - Name of test material (as cited in study report): Calcium sulfate dihydrate
- Analytical purity: 99.9%
- Lot/batch No.: Sigma Aldrich Lot. No. -109H0166
Constituent 1
Constituent 2
Test organisms
- Test organisms (species):
- Oryzias latipes
- Details on test organisms:
- TEST ORGANISM
- Common name: Japanese rice fish
- Age at study initiation: 5 months
- Length at study initiation: 2.7 ± 0.1 cm
- Weight at study initiation: 0.15 ± 0.02 g
- Feeding during test: No food was fed before 1 day prior to testing and during the test
ACCLIMATION
- Acclimation period: 7 days
Study design
- Limit test:
- yes
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 54.5 mg/L as CaCO3
- Test temperature:
- 242 - 24.8°C
- pH:
- 7.41 - 7.95
- Dissolved oxygen:
- 81.9 - 105.3%
- Nominal and measured concentrations:
- Limit test performed at a concentration 100 mg/L
- Details on test conditions:
- TEST SYSTEM
- No. of organisms per vessel: 7 (no replicates)
- Biomass loading rate: 8.7 L aquarium per 7 fish
OTHER TEST CONDITIONS
- Photoperiod:16/8 (light/dark)
- Light intensity: 1628 - 1816 lux
- Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 79 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- other: No mortalities observed
- Remarks on result:
- other: The LC50 for calcium sulfate dihydrate was >100 mg/L the result has been corrected for calcium sulfate anhydrous
- Details on results:
- There were no mortalities and no symptoms of intoxication were observed throughout the study.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The LC50 of calcium sulfate anhydrous is > 79 mg/L
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