Registration Dossier
Registration Dossier
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EC number: 675-511-0 | CAS number: 130336-16-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only short abstract available
Data source
Materials and methods
- Principles of method if other than guideline:
- not stated
- GLP compliance:
- not specified
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Kbs: NZW; New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: opposite untreated eye served as control
- Observation period (in vivo):
- Cornea, iris and conjunctivae of the eyes were observed at 1, 24, 48, 72 hours, and on 4, 5, 6
days after the test substance application. - Number of animals or in vitro replicates:
- not stated
Results and discussion
Applicant's summary and conclusion
- Interpretation of results:
- other: strong irritation
- Remarks:
- Criteria used for interpretation of results: other: Kay and Calandra Classification System
- Conclusions:
- Strong opacity of the cornea, no reaction to light of the iris, redness, chemosis and
secretion of the middle range were observed in two animals at 1 hour after the test substance
application. These symptoms continued to 7 days after the application, except for reaction
of the iris. The reaction of the iris disappeared in one animal on 5 days after the application,
and disappeared on 6 days after the application in the other animal.
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