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EC number: 700-457-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to GLP and OECD-guideline 423, Commission Regulation (EC) No 440/2008, US EPA OPPTS 870.1100 and Japan MAFF 8147.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Reaction mass of N-butylphosphorothioic triamide and N-propylphosphorothioic triamide
- EC Number:
- 700-457-2
- Molecular formula:
- Unspecified
- IUPAC Name:
- Reaction mass of N-butylphosphorothioic triamide and N-propylphosphorothioic triamide
- Details on test material:
- - Name of test material (as cited in study report): LIMUS-Sambaydestillation
- Test-substance No.: 07/0684-1
- Physical state: solid/yellowish
- Analytical purity: 87%
- Lot/batch No.: 8712 / 062
- Storage condition of test material: < -18°C
- Stability: stable over 5 days
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Wistar / Crl:WI (Han)
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Wiga GmbH, Sandhofer Weg 7, 97633 Sulzfeld, Germany
- Age at study initiation: Young adult animals (female animals approx. 10 – 11 weeks)
- Weight at study initiation: 173 - 184 g
- Fasting period before study: 16 h before administration
- Housing: single housing in Makrolon cages, type III
- Diet (e.g. ad libitum): VRF1(P); SDS Special Diets Services, 67122 Altrip, Germany.
- Water (e.g. ad libitum): tap water
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 20 - 80
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Remarks:
- Ph.Eur./DAB
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20 g/100 mL (2000 mg/kg b.w.) and 3 g/100 mL (300 mg/kg b.w.)
- Amount of vehicle (if gavage): 10 mL/kg b.w.
- Justification for choice of vehicle: Good homogeneity in olive oil Ph.Eur./DAB - Doses:
- 300 and 2000 mg/kg b.w.
- No. of animals per sex per dose:
- 6 (Administration 1: 3 animals; Administration 2: 3 animals)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Individual body weights shortly before administration (day 0), weekly thereafter and on the last day of obs ervation. Recording of signs and symptoms several times on the day of administration, at least once each workday for the individual animals.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross pathology
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 000 mg/kg bw
- Remarks on result:
- other: Clinical observation in the 2000 mg/kg test groups: impaired and poor general state, dyspnoea, piloerection, exsiccosis, staggering, salivation, ataxia and reduced feces.
- Mortality:
- One animal of the first 2000 mg/kg test group was found dead hour 3 after administration. Two animals of the second 2000 mg/kg test groups were found dead hour 2 and hour 3 after administration. No mortality occurred in the 300 mg/kg test groups.
- Clinical signs:
- other: Clinical observation in the 2000 mg/kg test groups revealed impaired and poor general state, dyspnoea, piloerection, exsiccosis, staggering, salivation, ataxia and reduced feces. Findings were observed from hour 0 through to study day 10 after administrat
- Gross pathology:
- No macroscopic pathologic abnormalities were noted in the animals examined on the last day of observation (2000 mg/kg: 3 females; 300 mg/kg: 6 females).
At necropsy the animals that died showed bilateral hydrothorax (ca. 2 mL), edema in all lobes of lung, dark spotted discoloration of all lobes of lung and congestion in heart, kidneys, stomach and intestine (2000 mg/kg: 3 females). At necropsy the animals that died showed bilateral hydrothorax (ca. 2 mL), edema in all lobes of lung, dark spotted discoloration of all lobes of lung and congestion in heart, kidneys, stomach and intestine (2000 mg/k: 3 females).
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this study the median lethal dose of LIMUS-Sambaydestillation after oral administration was found to be ca. 2000 mg/kg bodyweight in rats. According to the results of this study, the substance was classified R22 (according to Directive 67/548/EEC) and Acute toxicity oral Cat 4 (according to GHS (UN)).
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