Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 403-240-8 | CAS number: 106264-79-3 DM-C-TDA; DMTDA; ETHACURE (R) 300 CURATIVE
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- EEC B.1, EPA 560/6-83-001
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- - Range-finding test: 500, 3200 and 5000 mg/kg
- Main study: 1000, 1250, 1600 and 2500 mg/kg - No. of animals per sex per dose:
- - Range finding test: 3 groups of 2 animals (1 M, 1 F)
- Main study: 4 groups of 10 fasted rats (5M, 5F) - Control animals:
- no
- Preliminary study:
- A dose range finding study was performed using 3 groups of 2 animals (1 M, 1 F). Animals were administered test compound at 500, 3200 and 5000 mg/kg by oral gavage. None of the rats died at 500 mg/kg. All of the rats died at the other two dose groups. In the definitive study, 4 groups of 10 fasted rats (5M, 5F) were orally administered the test article at 1000, 1250, 1600 and 2500 mg/kg.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 515 mg/kg bw
- 95% CL:
- >= 960 - <= 2 048
- Mortality:
- Male: 1000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 1250 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 1600 mg/kg bw; Number of animals: 5; Number of deaths: 4
Male: 2500 mg/kg bw; Number of animals: 5; Number of deaths: 4
Female: 1000 mg/kg bw; Number of animals: 5; Number of deaths: 1
Female: 1250 mg/kg bw; Number of animals: 5; Number of deaths: 2
Female: 1600 mg/kg bw; Number of animals: 5; Number of deaths: 3
Female: 2500 mg/kg bw; Number of animals: 5; Number of deaths: 5 - Clinical signs:
- other: Signs of toxicity related to dose levels: A dose range finding study was performed using 3 groups of 2 animals (1M, 1F). Animals were administered test compound at 500, 3200 and 5000 mg/kg by oral gavage. None of the rats died at 500 mg/kg. All of the ra
- Gross pathology:
- Effects on organs:
a) 1000, 1250 and 1600 dose levels
Necropsy of animals dying in study revealed hemorrhagic stomach lesions, discolored lungs, hydrothorax, discolored fluid-filled bladders
b) 2500 mg/kg dose level
No visible lesions observed in any animal at terminal necropsy - Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral toxicity LD50 was found to be 1515 mg/kg bw for males/females. In conclusion, the test substance has to be classified Toxicity Category IV based on the results of this test.
- Executive summary:
The acute oral toxicity on rats was determined in a GLP study according to OECD guideline 401 and EU test method B.1. Vehicle was corn oil. A dose range finding study was performed using 3 groups of 2 animals (1 M, 1 F). Animals were administered test compound at 500, 3200 and 5000 mg/kg by oral gavage. None of the rats died at 500 mg/kg. All of the rats died at the other two dose groups. In the definitive study, 4 groups of 10 fasted rats (5M, 5F) were orally administered the test article at 1000, 1250, 1600 and 2500 mg/kg.
Signs observed were decreased activity, ptosis, piloerection, decreased muscle tone, abnormal gait, abnormal stance, poor grooming, diarrhea, chromodacryorrhea and prostration. One of 10 died at 1000 mg/kg, 2110 at 1250 mg/kg, 7110 at 1600 mg/kg and 9/10 at 2500 mg/kg. Necropsy of dead animals revealed hemorrhagic lesions in the stomach, discolored intestines, discolored lungs, hydrothorax and discolored fluid filled bladders.
The acute oral toxicity LD50 was found to be 1515 mg/kg bw for males/females. In conclusion, the test substance has to be classified Toxicity Category IV based on the results of this test.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 515 mg/kg bw
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- EEC B.3
- GLP compliance:
- yes
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: No signs. None of the rabbits died throughout the study.
- Gross pathology:
- Effects on organs:
No test article related lesions observed. - Other findings:
- Signs of toxicity (local):
Slight to moderate erythema was observed at 24 hours after initiation of exposure (exposure time was 24 hrs.) - Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- According to OECD guideline 402 the acute dermal LD50 was determined to be > 2000 mg/kg. Thus, the test substance can be considered as not acutely toxic via the dermal route.
- Executive summary:
According to OECD Guideline 402 the test material was applied at a dose of 2000 mg/kg to five male and five female rabbits. The substance was left in contact with the skin for 24 hours. None of the rabbits died during the study, slight to moderate erythema was observed in every animal at 24 hours after initiation of exposure. No test article related lesions observed in gross pathology. The acute dermal LD50 was determined to be greater than 2000 mg/kg.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
Available study
Justification for selection of acute toxicity – dermal endpoint
Available study
Justification for classification or non-classification
The acute oral toxicity LD50 was found to be 1515 mg/kg bw for male/female rats. In conclusion, the test substance has to be classified Toxicity Category IV based on the results of this test.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.