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EC number: 203-121-9 | CAS number: 103-54-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17.-21.08.1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- Feb. 1987
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EEC Guideline B.5 "Acute Toxicity (Eye Irritation)", .Jan. 1997
- Version / remarks:
- Jan. 1997
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Cinnamyl acetate
- EC Number:
- 203-121-9
- EC Name:
- Cinnamyl acetate
- Cas Number:
- 103-54-8
- Molecular formula:
- C11H12O2
- IUPAC Name:
- cinnamyl acetate
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Charles River, Deutschland GmbH, Stolzenseeweg 32-36, 88353 Kißleg
- Weight: 2.0 - 2.3 kg b.wt.
- Housing: individually in PPO cages (floor area: 2576 cm2) with perforated floor.
- Diet: pelleted complete rabbit diet "Altromin 2123" from Altromm, D-32791 Lage, Lippe; ad libitum
- Water: bottles with domestic quality drinking water acidified with hydrochloric acid to pH 2.5.
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature: 20°C ± 3°C
- Humidity: 55% ± 15%
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): cycle of 12 hours light (6 - 18h) and 12 hours darkness
DATES:
The experimental work was carried out between 17.08.1999 and 21.08.1999.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL
- Concentration (if solution): undiluted - Duration of treatment / exposure:
- single treatment
- Observation period (in vivo):
- 1, 24, 48 and 72 hours after treatment
- Number of animals or in vitro replicates:
- 4
- Details on study design:
- APPLICATIN OF TEST SUBSTANCE:
0.1 mL of the test article was placed in the left eye of the rabbits by gently pulling the lower lid away from the eyeball to form a cup into which the test article was dropped. The lids were then gently held together for 1 second. The eyes were not rinsed after the treatment
EXAMINATION:
The eyes were examined and the grade of ocular reaction was recorded one hour and 24 hours later. After the first 24h reading, fluorescein was instilled. After rinsing with 20 mL 0.9% sodium chloride solution, the eyes were examined again using UV-light to detect possible corneal damage. The eyes were also examined 48 and 72 hours after the treatment.
SCORING SYSTEM: See 'Any other information on materials and methods'
TOOL USED TO ASSESS SCORE: fluorescein - UV-light
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: #1, #2, #3, #4
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- iris score
- Basis:
- animal: #1, #2, #3, #4
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal: #1, #2, #3, #4
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- chemosis score
- Basis:
- animal: #1, #2, #3, #4
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritant / corrosive response data:
- One hour after application of the test article all animals showed some conjunctival vessels definitely injected and some swelling above normal, however, after 24 hours the animals did not show any signs of eye irritation.
Any other information on results incl. tables
Scores for ocular lesions:
After 1h, all rabbits had a score of 1 for conjunctival redness and for chemosis. All other scores were 0 at this time point.
After 24h, no more redness or chemosis was observed. All animals received scores of 0 on all examined parameters.
* individual mean score: only the scores from the readings after 24, 48 and 72 hours are included in the calculation of the individual mean scores.
Rabbit No/Weight per kg | Parameters | Individual mean score* |
1581/2.3 | cornea opacity | 0.00 |
iris | 0.00 | |
conjunctiva redness | 0.00 | |
conjunctiva chemosis | 0.00 | |
1595/2.0 | cornea opacity | 0.00 |
iris | 0.00 | |
conjunctiva redness | 0.00 | |
conjunctiva chemosis | 0.00 | |
1596/2.2 | cornea opacity | 0.00 |
iris | 0.00 | |
conjunctiva redness | 0.00 | |
conjunctiva chemosis | 0.00 | |
1594/2.0 | cornea opacity | 0.00 |
iris | 0.00 | |
conjunctiva redness | 0.00 | |
conjunctiva chemosis | 0.00 |
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008.
- Conclusions:
- According to the CLP regulation the test item shall not be classified as eye irritating.
- Executive summary:
The eye irritant effect of the test substance was investigated according to the OECD Guideline 405 and EEC Guideline B.5. The study is in compliance with GLP.
Four female albino rabbits were exposed to 0.1 mL of the test article in the left eye, while the other eye remained untreated and served as control.
The eyes were examined and the changes were graded according to a numerical scale one hour, 24, 48 and 72 hours after dosing.Very slight signs of irritation were observed on the treated eyes one hour after exposure. However, after 24 hours no signs of irritation were seen, indicating the reversible nature of the effects.
According to the CLP regulation the test item shall not be classified as eye irritating.
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