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EC number: 207-322-2 | CAS number: 462-08-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted in GLP compliance and in accordance with OECD Guideline No 420. Identity is not completely clear, therefore reliability 2
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- 3AP
- IUPAC Name:
- 3AP
- Test material form:
- other: solid
- Details on test material:
- batch: 08Z359
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Laberateries UK Limited, Bicester, Oxon, UK.
- Age at study initiation: eight to twelve weeks
- Weight at study initiation: 160 - 182 g
- Fasting period before study: overnight
- Housing: in groups of up to four in suspended solid-floor polypropylene cages furnished with woodflakes
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least five days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 to 25°C
- Humidity (%): 30 to 70%
- Air changes (per hr): at least fifteen changes per hour
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 30 mg/ml, 5 mg/ml, 0,5 mg/ml
- Amount of vehicle (if gavage): 10 ml /kg
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: ln the absence of data regarding the oral toxicity of the test material, 300 mg/kg was
chosen as the starting dose. - Doses:
- 300 mg/kg, 50 mg/kg, 5 mg/kg
- No. of animals per sex per dose:
- 300 mg/kg: 1 female
50 mg/kg: 1 female
5 mg/kg: 5 females - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical Observations: 0,5, 1, 2, and 4 hours after dosing.Morbidity and mortality checks were made twice daily.
Individual bodyweights: Day 0 (the day of dosing) and on Days 7 and 14 or at death.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: yes
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- >= 5 - <= 50 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 5 mg/kg: no deaths
50 mg/kg: The animal was found dead approximately five and a half hours after dosing
300 mg/kg: The animal was found dead thirty minutes after dosing. - Clinical signs:
- other: 5 mg/kg: No signs of systemic toxicity were noted du ring the observation period 50 mg/kg: Signs of systemic toxicity noted were hunched posture, occasional body tremors, increased salivation and pilo-erection. 300 mg/kg: No signs of systemic toxicity wer
- Gross pathology:
- 5 mg/kg: No abnormalities were noted at necropsy.
50 mg/kg: Abnormalities noted at necropsy were abnormally red lungs, dark liver, dark kidneys and slight haemorrhage of the non-glandular region of the stomach.
300 mg/kg: No abnormalities were noted at necropsy
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 based on GHS criteria
- Conclusions:
- The acute oral median Iethal dose (LD50) of the test material in the female Wistar strain
rat was estimated to be in the range of 5 - 50 mg/kg bodyweight (Globally Harmonised
Classification System- Category 2) in this study.
This study is not used for GHS classification of the substance, because at the critical dose of 50 mg/kg only one rat was tested. For Acute Oral Toxicity classification the H-phrase H301 of another study was taken. This study is more reliable because 10 rats were tested with 50 mg/kg.
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