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Diss Factsheets
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EC number: 700-291-0 | CAS number: 1000701-92-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: only secondary literature
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Acute 9-day and 13-week inhalation studies of ethylene glycol monohexylether
- Author:
- Klonne, DR et al.
- Year:
- 1 987
- Bibliographic source:
- Fundam. Appl. Toxicol. 8, 198-206
- Reference Type:
- publication
- Title:
- No information
- Author:
- Klonne, DR et al.
- Year:
- 1 986
- Bibliographic source:
- The Toxicologist 6 (1), 60, Abstract No. 237
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 005
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Hexylglycol (EGHE)
- IUPAC Name:
- Hexylglycol (EGHE)
- Reference substance name:
- 2-hexyloxyethanol
- EC Number:
- 203-951-1
- EC Name:
- 2-hexyloxyethanol
- Cas Number:
- 112-25-4
- Molecular formula:
- C8H18O2
- IUPAC Name:
- 2-(hexyloxy)ethanol
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Duration of treatment / exposure:
- 13 weeks
- Frequency of treatment:
- 6 hours/day, 5 days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.12, 0.25 bzw. 0.43 mg/l (20, 41, 71 ppm)
Basis:
- No. of animals per sex per dose:
- 20
- Control animals:
- yes, concurrent no treatment
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 0.25 other: mg/l
- Sex:
- male/female
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
Es wurden 20 maennliche und 20 weibliche Tiere in derBei den weiblichen Tieren aller und den maennlichen Tieren der hoechsten Dosisgruppe wurde im Urogenitalbereich Naesse
Kontrollgruppe und den drei Dosisgruppen eingesetzt. Zwei
Tage nach Ende der Expositionszeit wurden 10 Tiere pro
Geschlecht und Gruppe getoetet; die restlichen 10 Tiere pro
Geschlecht und Gruppe wurden nach 4 Wochen Nachbeobachtung
getoetet.
des Fells festgestellt. Verminderte Koerpergewichtsentwicklung wurde bei den Tieren beiden Geschlechts in der hoechsten Dosisgruppe und bei den weiblichen Tieren der mittleren Dosisgruppe festgestellt.
Das relative, teilweise auch das absolute Lebergewicht war bei den Tieren der hoechsten Dosisgruppe, in geringerem
Ausmass auch in der mittleren Dosisgruppe signifikant erhoeht (beide Geschlechter), jedoch ohne makroskopische
bzw. histologische Veraenderungen. Hiermit moeglicherweise in Zusammenhang stand laut Angabe der Autoren eine
Verminderung der Aspartat-, Alaninaminotransferase und der Sorbitoldehydrogenase Aktivitaet, sowie eine Erhoehung der
alkalischen Phosphatase bei den weiblichen Tieren der hoechsten Dosisgruppe. Bei den maennlichen Tieren der
beidenhohen Dosisgruppen wurde ein Anstieg der relativen und der absoluten Lebergewichte festgestellt, jedoch ohne
makroskopische und histologische Entsprechung. Die erhoehten relativen bzw. die erhoehten relativen und
absoluten Lebergewichte persistierten bis zum Ende der Nachbeobachtung bei den maennlichen bzw. den weiblichen
Tieren der hoechsten Dosisgruppe. Die haematologischen und die Urin-Parameter, sowie die weiteren makroskopischen und
histologischen Untersuchungen zeigten keine Veraenderungen im Vergleich zur Kontrollgruppe.
Applicant's summary and conclusion
- Executive summary:
Hexylglycol is the parent compound and occurs together with the sodium salt of the submission substance identity. For systemic toxicity, the glycol ether is regarded as a worst case as it is a good solvent and most probably taken up in higher percentages than the ionic salt.
Testing of this specific endpoint is additionally advised against for the submission substance because of its corrosive properties.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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